Plasticity in corticomotor pathways following a tooth-clenching task and masseter sensitization is impaired in bruxers compared to matched control individuals

Not Applicable

• Conditions: Facial pain; C07.793.099; F01.145.466.132; F01.470.315

• Registration Number: RBR-2wcyvss
• Lead Sponsor: Aarhus University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-03-10
• Study Start: 2022-04-20
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

The volunteers participating in the study were in good general health; of both gender, aged less than 18 years; and with no orofacial pain complaints in the last 30 days or chronic pain disorders.

Exclusion Criteria

Presence of dental or medical illness; regular intake of medication such as antidepressants; anticonvulsants; or nonsteroidal anti-inflammatories; any diagnosis of psychiatric or personality disorders; and the presence of contraindications to transcranial magnetic stimulation (i.e., metal implants in the head; implanted electronic devices; history of epilepsy and if they were pregnant) were defined as exclusion criteria.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Right masseter muscle motor evoked potential (MEP) amplitude was assessed at two-time points, i.e., at baseline and 72 h post-either nerve growth factor or isotonic saline injection in combination with a tooth-clenching task. The MEPs were assessed by stimulus-response (S–R) curves and motor cortex mapping. S–R curves were constructed in steps of MT, from T–10% T+20% to T+60% (i.e., respectively at 90%, 100%, 120%, and 160% MT), where MT was the resting or active MT measured at the specific time of creating the S–R curve.