Integrating motivation, cognition and action: cortical control of striatal processing

Completed

Conditions: niet van toepassing
not applicable

Registration Number: NL-OMON36652

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Healthy, right handed participants (males and females) age 18-35 years. All participants will have normal or corrected to normal vision.

Exclusion Criteria

Contra-indications for TMS and fMRI: drug abuse, head trauma, neurological or psychiatric illness, pregnancy, heart disease, claustrophobia, cardiac pacemakers, metal objects in the body, medication pumps, tricyclic antidepressants, neuroleptics and a family history of neurological illness, psychiatric illness or epilepsy.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Reaction times, error rates and brain activity (fMRI BOLD response) will be<br /><br>used to test whether cTBS over the OFC, dlPFC, and PMC will uniquely affect<br /><br>performance on the (interaction between) 3 components of the task and whether<br /><br>the BOLD response is altered in the VS, CN, or putamen, respectively and the<br /><br>interaction between the striatal regions. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>In order to assess functional connectivity patterns between the striatal and<br /><br>cortical areas, we will obtain resting state scans before and after cTBS<br /><br>intervention.<br /><br>We aim to test whether the cTBS effects are confined to those cortico-striatal<br /><br>loops predicted to be affected on the basis of known anatomy in non-human<br /><br>primates. Furthermore, this will enable us to investigate whether cTBS<br /><br>influences cortico-striatal circuits only when those circuits are taxed by a<br /><br>particular task, or whether those effects influence the ongoing pattern of<br /><br>functional connectivity in the cortico-striatal system, irrespective of task<br /><br>performance.</p><br>