Comparison of Genotype-Based Dietary Counseling Versus Standard Dietary Counseling on Weight Loss and Fat Mass Reduction
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- Change in Fat Mass (%)
研究概览
简要总结
This study aims to compare the effects of genotype-based dietary counseling with standard dietary counseling based on general recommendations on weight loss and reduction of body fat. Participants will receive individualized dietary guidance either informed by genetic information or based on conventional dietary guidelines. Changes in body weight and body composition will be assessed over the course of the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults aged ≥18 years
- •Body mass index (BMI) ≥25 kg/m²
- •Greek-speaking (able to read and understand Greek and provide informed consent)
- •Willing and able to participate in dietary counseling and study assessments for the duration of the study
排除标准
- •Current use of pharmacological treatments for weight loss, including but not limited to GLP-1 receptor agonists, appetite suppressants, or other anti-obesity medications
- •Participation in any structured weight-loss intervention or program within the previous 3 months, including commercial weight-loss programs or medically supervised dietary interventions
- •Use of medications known to significantly affect body weight or body composition, such as systemic corticosteroids, antipsychotic medications, or medications for thyroid disorders
- •Pregnancy or lactation
- •Presence of medical conditions that may affect body weight, metabolism, or nutritional status, including untreated thyroid disease, severe gastrointestinal disorders, or endocrine disorders
研究组 & 干预措施
Genotype-Based Dietary Counseling
Participants in this arm will receive dietary counseling tailored according to their genetic profile. Dietary recommendations will be provided by qualified nutrition professionals and will be based on individual genetic information in combination with standard nutritional principles. The counseling will be delivered over the course of the intervention period.
干预措施: Genotype-Based Dietary Counseling (Behavioral)
Standard Dietary Counseling
Participants in this arm will receive dietary counseling based on general dietary guidelines and standard nutritional recommendations. Counseling will be provided by qualified nutrition professionals over the course of the intervention period, without the use of genetic information.
干预措施: Standard Dietary Counseling (Behavioral)
结局指标
主要结局
Change in Fat Mass (%)
时间窗: baseline to end of intervention (12 months)
Change in whole-body fat mass percentage from baseline to end of the intervention
次要结局
- Change in Body Weight(baseline to end of intervention (12 months))
- Change in Lipid Profile(baseline to end of intervention (12 months))
研究者
Angeliki Kapellou
Principal Investigator
Metropolitan College