Effect of platelet rich fibrin (PRF) in formation of tooth apex in cases of immature front teeth

Recruiting

• Conditions: Non-vital open apex immature anterior permanent teeth

• Registration Number: CTRI/2012/11/003086
• Lead Sponsor: All India Institute of Medical Science

Brief Summary

It is a pilot clinical study for treatment of cases presenting immature anterior   permanent teeth. After control of intra canal infection by chemo-mechanical means,  indigenous stem cells residing in the periapical area of teeth being treated are stimulated by intentional over-instrumentation beyond the apical foramen and platelet rich fibrin prepared from patients blood  be placed inside the canal and coronal restoration is placed to prevent micro-leakage and future reinfection

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-09
• Last Update Posted: 2012-10-19

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• A)Patients having anterior maxillary non-vital, immature teeth with open apex with or without radiographic evidence of periapical lesion.
• B)Healthy patients with no systemic disorder.

Exclusion Criteria

Systemic conditions that limit the invasive procedures and which can compromise the healing response.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Complete control and resolution of clinical signs and symptoms such as pain, swelling, inflammation and restoration of function. Radiographic evidence of healing of periapical lesions showing disappearance or reduction in size of the lesion. Radiographic evaluation of dentinal wall thickening and elongation of root	Follow up at 3,6 9,12 months

Secondary Outcome Measures

Name	Time	Method
Seal of mineralized tissue at the root apices showing periapical healing, root lengthening, thickening of lateral dentinal walls, apical closure	Follow up at 3,6 9,12 months

Trial Locations

Locations (1)

Department of Conservative Dentistry and Endodontics Centre for Dental Education and Research; 🇮🇳 Delhi, DELHI, India

Department of Conservative Dentistry and Endodontics Centre for Dental Education and Research

🇮🇳Delhi, DELHI, India

Nikhil Bansal

Principal investigator

8585902602

dr_nik_bansal@yahoo.co.in