Sleep Disordered Breathing in Patients With Chronic Pain and Long Term Opiate Therapy
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Prevalence of sleep disordered breathing in patients on long term opiates.
研究概览
简要总结
Lay title: A study of breathing pauses during sleep in patients on long term opiates.
Sleep apnoea is a term which refers to frequent breathing pauses during sleep. Breathing can stop at night due to the upper airway collapsing (Obstructive sleep apnoea)or reduced signals from the brain driving breathing (central sleep apnoea). Clinical observation has noticed that patients on opiates have an increase in sleep apnoea.
Hypothesis: This study looks at the relationship of opiates (when used for patients chronic pain) and the occurrence of sleep apnoea. It is expected that there will be an increase in sleep apnoea (particularly of the central variant) particularly in patients on long term opiates.
详细描述
The purpose for this study is to test the hypothesis that sleep disordered breathing is more prevalent amongst a group of patients on high dose opiates for chronic pain.
Aims
- To define the prevalence of sleep disordered breathing in a group of patients on oral morphine for chronic pain.
- To determine the prevalence of respiratory failure in this cohort of patients. Patients on long term opiates (>6 months) from an outpatient pain clinic population on long acting morphine formulations > 40 mg/day, Oxycontin 30 mg/day, and Methadone > 20 mg/day were prospectively recruited. Home polysomnograms were done on them. During their clinical review they have spirometry, arterial blood gases, psychomotor vigilance tests done on them.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients on long acting Morphine >40mg/day, Oxycontin >30mg/day, and Methadone >20mg/day were contacted.
- •Stable opiate dose for 2 weeks
- •Lives within 80KM of FMC
排除标准
- •Significant CCF/CVA
- •Severe COPD
- •Major Psychiatric illness
- •History of substance abuse in the last 3 months
结局指标
主要结局
Prevalence of sleep disordered breathing in patients on long term opiates.
时间窗: 18 months
次要结局
- Prevalence of ventilatory failure in this cohort(18 months)