NL-OMON35955招募中不适用
Immune response against Coxiella burnetii in Chronic Q-fever - Immune response against Coxiella burnetii in Chronic Q-fever
niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 990 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 990
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Chronic Q-fever patients:
- •- Proven or probable chronic Q fever according to the recent consensus of the Dutch workgroup on Q-fever;Q-fever fatigue syndrome (QFS) patients:
- •- Laboratory-proven acute Q fever in the 3 years before presentation and/or positive serology fitting a past infection with Coxiella burnetii
- •- AND being severely fatigued, defined by scoring 35 or higher on the subscale fatigue severity of the CIS
- •- AND being fatigued for at least 6 months;Patients with past Q-fever infection without chronic infection or QFS
- •- A history of laboratory-proven acute Q-fever infection by either PCR on sera or serology fitting acute infection
- •- No chronic sequelae at least after 12 months of follow up;Healthy serologic negative volunteers:
- •- Negative Q-fever serology;Vascular patients with chronic Q-fever undergoing surgery for infected atherosclerotic aorta aneurysm (AAA) :
- •- Proven chronic Q-fever infection with infection of the vascular wall seen on CT, PET-CT or ultrasonography
- •- Necessity of resection;Vascular patients undergoing surgery, either with AAA or AOD
- •- For patients with uninfected AAA: An aneurysm of the aorta abdominalis for which resection with prosthetic replacement is necessary
- •- For patients with AOD: An obstructive defect in the aorta or iliacal artery for which resection with prosthetic replacement is necessary ;Seropositive individuals reporting no history of Q-fever
- •- Serology fitting past infection
- •- No reported history of acute Q-fever ;Seropositive individuals with a history of acute Q-fever
- •- A history of proven acute infection by either PCR on sera or serology fitting acute infection
- •- No chronic sequelae at least after 12 months of follow up;Seropositive individuals with QFS
- •- Laboratory-proven acute Q fever in the 3 years before presentation and/or positive serology fitting a past infection with Coxiella burnetii
- •- AND being severely fatigued, defined by scoring 35 or higher on the subscale fatigue severity of the CIS
- •- AND being fatigued for at least 6 months;Seropositive indivuals with chronic Q-fever
- •- Proven or probable chronic Q fever according to the recent consensus of the Dutch workgroup on Q-fever;Seronegative individuals (controls) living in the endemic area without a history of Q-fever
- •- Negative Q-fever serology
- •- Living in endemic area
排除标准
- •Age <18 years
研究者
相似试验
招募中
不适用
Effect of Coxiella burnetii infection on health status of patients following an outbreak of Q fever.Coxiella burneti infection1003913510024970Query feverNL-OMON32794niversitair Medisch Centrum Sint Radboud146
进行中（未招募）
1 期
CoVacc - Immune response to vaccination against Covid-19Individuals with and without pre-existing immunity to Covid-19.EUCTR2021-000683-30-SEmeå university3,000
进行中（未招募）
1 期
MenBvac vaccination efficiencyImmunogenic Study, in french children living in the region of Normandy, France, after vaccination for B:14:P1.7,16, to evaluate the longer-term persistence of antibodies against B:14P1.7,16. bacterial strain.MedDRA version: 14.1Level: HLTClassification code 10027203Term: Meningeal bacterial infectionsSystem Organ Class: 10029205 - Nervous system disordersEUCTR2011-006209-83-FRCHU - Hôpitaux de Rouen
进行中（未招募）
1 期
MenBVac vaccination efficiencyImmunogenic Study, in french children living in the region of Normandy, France, after vaccination for B:14,P1-7,16 bacterial strain.MedDRA version: 14.1Level: HLTClassification code 10027203Term: Meningeal bacterial infectionsSystem Organ Class: 10029205 - Nervous system disordersEUCTR2011-006268-27-FRCHU - Hôpitaux de Rouen
已完成
不适用
Evaluation of Crocina on The Cellular Immune Responses in Osteoarthritis PatientsOsteoarthritis.Polyarthrosis, unspecified Generalized osteoarthritis NOSIRCT2015021910507N2Research Chancellor, Mashhad University of Medical Sciences40