ACTRN12618001449224尚未招募未知
The effect of a beta-3 adrenergic receptor agonist on metabolic disease in humans.
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 20 Years 至 50 Years（—）
- 性别
- All
入选标准
- •Age 20-50 years
- •BMI: 30-40 kg/m2
- •HOMA-IR: greater than or equal to 2.0
排除标准
- •Alcohol consumption >3 (male) or >2 (female) standard drinks per day
- •Blood ALT concentration >3 times upper limit of normal (ULN) (ULN: female <20 IU/l, male <30 IU/l)
- •Hepatitis or autoimmune liver disease
- •History of type 1 or 2 diabetes
- •History of obstructive urinary symptoms
- •History of established cardiovascular disease (prior hospitalisation or medication for any cardiovascular disease or risk factor)
- •Currently taking any prescription medications that alter cardiometabolic parameters, prior use of anti-hypertensive medications and medications primarily acting via ß-ARs. Oral contraceptives are acceptable if treatment has been established for greater than 6 months.
- •Established renal disease or eGFR <60 ml/min/1.73m2
- •Pregnant or breastfeeding women
- •History of cancer other than non-melanoma skin cancer
- •History of major psychiatric illness, psychosis or major depressive disorder
研究者
相似试验
已完成
不适用
The effect of Beta-Adrenergic receptor blockade on sympathetic activity and Coagulation in patients with Heart failure (BACH-F study).1. Heart failure<br />2. Hemostasis<br />3. Sympathetic activity.NL-OMON21698P.W. Kamphuisen, internist, Vasculair Geneeskundige.80
进行中（未招募）
不适用
The effect of beta-adrenergic receptor blockade on sympathetic activity and coagulation in patients with heart failure (BACH-F study) - BACH-F studyCongestive heart failureMedDRA version: 9.1Level: LLTClassification code 10010684Term: Congestive heart failureEUCTR2007-001994-27-NLetherlands Heart Foundation80
尚未招募
不适用
The effect of beta-adrenergic receptor blockade on sympathetic activity and coagulation in patients with heart failure (BACH-F study)Congestive heart failuresystolic heart failure10019280NL-OMON31270Academisch Medisch Centrum80
进行中（未招募）
不适用
(VAPOR trial)Overactive bladderJPRN-jRCTs071190040Seki Narihito60
已完成
不适用
Effect of Mirabegron (beta 3-adrenergic receptor agonist) on overactive bladder patients : a functional brain imaging studyOveractive bladderJPRN-UMIN000014150Hokkaido University Graduate School of Medicine10