Effects of intravascular contrast media on platelet function in patients undergoing coronary angiography
Not Applicable
Completed
- Conditions
- Coronary artery diseaseCirculatory SystemAtherosclerotic heart disease
- Registration Number
- ISRCTN51509735
- Lead Sponsor
- Centre for Health Science (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 12
Inclusion Criteria
1. Male
2. Aged 50-70
3. Clinical reason for coronary angiography
4. Coronary artery disease defined by coronary angiography
5. No history of diabetes, fasting blood glucose < 6 mmol/l, HbA1c < 6.5%
6. Taking aspirin but not clopidogrel
7. Non-smoker
Exclusion Criteria
1. Participation in pharmacological study within last 3 months
2. Taking clopidogrel
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Assessment of platelet function and cellular oxidative stress using flow cytometry (platelet-monocyte binding, oxidative stress markers)<br>2. Plasma samples will be assessed for tissue plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) to help identify whether there is any effect on fibrinolytic capacity
- Secondary Outcome Measures
Name Time Method 1. To assess the ability of contrast media to generate oxygen-centred free radicals