The Correlation of Clinical and Ultrasonographic Findings in Dorsoradial Wrist Pain Patients: Cross Sectional Study

Completed

• Conditions: Carpometacarpal (CMC) Joint Arthritis; De Quervain Disease; Ganglion Cyst; Radial Neuropathy

• Registration Number: NCT06980779
• Lead Sponsor: Fatih Sultan Mehmet Training and Research Hospital

Brief Summary

This study aims to investigate the correlation between ultrasonographic and clinical findings in dorsoradial wrist pain. There are several etiologies for dorsoradial wrist pain, including carpometacarpal joint arthritis, De Quervain's tenosynovitis, proximal and distal intersection syndrome, Wartenberg syndrome, and ganglion cysts. In these clinical scenarios, certain physical examination tests are utilized, such as the Finkelstein test for De Quervain's tenosynovitis; however, this test may also yield positive results in cases of severe joint arthritis. Ultrasonography is proposed as a complementary tool for differential diagnosis. The investigators aim to examine the correlation between clinical test results and ultrasonographic parameters such as tendon thickness in the first extensor compartment, carpometacarpal joint synovitis, cortical irregularities, and the presence of osteophytes. Functional status will be assessed using the QuickDASH and FIHOA questionnaires.

Detailed Description

In the assessment of the first carpometacarpal (CMC) joint, the following ultrasonographic parameters will be evaluated: synovitis, presence of osteophytes, joint surface irregularity, and Doppler signal activity. Additionally, conventional hand radiographs of all participants will be reviewed to support the imaging findings.

For the evaluation of De Quervain's tenosynovitis, tendon sheath thickness, tendon cross-sectional area, and intratendinous Doppler activity will be measured. At the anatomical intersection zones of the first dorsal compartment, the presence of peritendinous fluid and associated Doppler activity will also be assessed to identify potential sites of friction or inflammation.

Assessment of the superficial radial nerve will include measurement of its cross-sectional area. A cross-sectional area exceeding one square millimeter will be considered indicative of possible neuropathy.

Study Timeline

• Status Verified: 2024-06
• Study Start: 2024-07-29
• Primary Completion: 2024-10-06
• Study Completion: 2024-10-06
• Study First Submitted: 2025-03-23
• Study First Submitted QC: 2025-05-12
• Last Update Submitted: 2025-05-12
• Study First Posted: 2025-05-20
• Last Update Posted: 2025-05-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• pain in dorsoradial wrist

Exclusion Criteria

• known rheumatological disease
• history of forearm, wrist, hand fracture
• history of forearm, wrist, hand operation
• mental retardation
• history of major trauma in forearm, wrist and hand
• fibromyalgia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Odds Ratio of First Extensor Compartment Tendon Sheath Thickness Associated with De Quervain Disease	At the time of enrollment	To quantify the association between increased tendon sheath thickness and clinical diagnosis of De Quervain tenosynovitis using logistic regression analysis.
Odds Ratio of Synovial Hypertrophy in CMC Joint Associated with Carpometacarpal Arthritis	At the time of enrollment	To assess the strength of association between ultrasonographic synovial hypertrophy and clinical diagnosis of carpometacarpal joint arthritis.
Sensitivity of Ultrasonographic Parameters for Diagnosing Dorsoradial Wrist Pathologies	At the time of enrollment	To assess the diagnostic sensitivity of individual ultrasonographic findings (e.g., tendon sheath thickness, synovial hypertrophy) for detecting De Quervain tenosynovitis and CMC arthritis.
Specificity of Ultrasonographic Parameters for Diagnosing Dorsoradial Wrist Pathologies	At the time of enrollment	To assess the diagnostic specificity of individual ultrasonographic findings for identifying De Quervain tenosynovitis and CMC arthritis.

Trial Locations

Locations (1)

University of Health Sciences, FSM Training and Research Hospital, Istanbul; 🇹🇷 Istanbul, Ataşehir, Turkey