Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
- Conditions
- Advanced Non-Small Cell Lung CancerMetastatic Non-Small Cell Lung Cancer
- Interventions
- Registration Number
- NCT04613596
- Lead Sponsor
- Mirati Therapeutics Inc.
- Brief Summary
The Phase 2 portion of this study evaluates the efficacy and safety of MRTX849 monotherapy and in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS and who are candidates for first-line treatment.
The Phase 3 portion of the study compares the efficacy of adagrasib in combination with pembrolizumab versus pembrolizumab in patients with unresectable, locally advanced or metastatic nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS \>=50% and who are candidates for first line treatment.
- Detailed Description
The Phase 2 portion of this study will evaluate the efficacy and safety of MRTX849 as monotherapy and in combination with pembrolizumab. There will be 3 cohorts of patients, all of whom have KRAS G12C mutation, have advanced or metastatic NSCLC, and are candidates for first-line treatment. 2 cohorts have PD-L1 TPS score \<1% and are randomized to MRTX849 monotherapy or MRTX849 in combination with pembrolizumab. The 3rd cohort has PD-L1 TPS score of 1% or higher and is treated with MRTX849 and pembrolizumab
The Phase 3 portion of the study will randomize patients with squamous or nonsquamous NSCLC with KRAS G12C mutation and TPS \>=50% in the first-line setting to adagrasib plus pembrolizumab or pembrolizumab. Primary efficacy objective is to compare efficacy between experimental and comparator arms. Secondary and exploratory objectives include evaluation of secondary efficacy endpoints, safety and tolerability, adagrasib PK, PROs, and correlative genomic biomarkers for the combination regimen in the study population.
MRTX849 is an orally available small molecule inhibitor of KRAS G12C, and Pembrolizumab (KEYTRUDA®) is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 806
-
Phase 2: Histologically confirmed diagnosis of unresectable or metastatic NSCLC with KRAS G12C mutation and any PD-L1 TPS
-
Phase 3: Histologically confirmed diagnosis of unresectable or metastatic squamous or nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS >=50%
-
Phase 3: Presence of evaluable or measurable disease per RECIST
-
Phase 3: CNS Inclusion - Based on screening brain imaging, patients must have one of the following:
- No evidence of brain metastases
- Untreated brain metastases not needing immediate local therapy
- Previously treated brain metastases not needing immediate local therapy
-
Phase 2 and Phase 3: Prior systemic treatment for locally advanced or metastatic NSCLC including chemotherapy, immune checkpoint inhibitor therapy, or a therapy targeting KRAS G12C mutation (e.g., AMG 510).
-
Phase 2: Active brain metastases
-
Phase 3: Patients with known central nervous system (CNS) lesions must not have any of the following:
- Any untreated brain lesions > 1.0 cm in size
- Any brainstem lesions
- Ongoing use of systemic corticosteroids for control of symptoms of brain lesions at a total daily dose of > 10 mg of prednisone (or equivalent) prior to randomization.
- Have poorly controlled (> 1/week) generalized or complex partial seizures, or manifest neurologic progression due to brain lesions notwithstanding CNS-directed therapy
-
Phase 3: Radiation to the lung > 30 Gy within 6 months prior to the first dose of study treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Phase 2 Cohort 1a: PD-L1 TPS <1% Adagrasib Cohort 1a: Adagrasib twice daily (BID) in combination with pembrolizumab Phase 2 Cohort 2: PD-L1 TPS ≥1% Adagrasib Cohort 2: Adagrasib BID in combination with pembrolizumab Phase 2 Cohort 1b: PD-L1 TPS <1% Adagrasib Cohort 1b: Adagrasib BID monotherapy Phase 3 Cohort 3 Investigational Arm Adagrasib Adagrasib BID in combination with pembrolizumab Phase 3 Cohort 4 Comparator Arm Pembrolizumab Pembrolizumab
- Primary Outcome Measures
Name Time Method Phase 2: To evaluate the efficacy of Adagrasib monotherapy and in combination with pembrolizumab administered to patients having advanced/metastatic NSCLC. 22 months Objective Response Rate (ORR) as defined by Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1)
Phase 3: To compare efficacy of Adagrasib in combination with pembrolizumab versus pembrolizumab 36 months Progression Free Survival per RECIST 1.1 by Blinded Independent Central Review (BICR) and Overall Survival
- Secondary Outcome Measures
Name Time Method Phase 2: To characterize the safety and tolerability of study treatments in selected populations 22 months Safety characterized by type, incidence, severity, timing, seriousness and relationship to study treatment of adverse events and laboratory abnormalities.
Phase 2: Duration of Response 22 months Defined as the time from date of the first documentation of objective tumor response (CR or PR) to the first documentation of either Progression of Disease (PD) or death due to any cause, whichever occurs first.
Phase 2: Progression Free Survival 22 months Defined as time from first study treatment until disease progression or death from any cause, whichever occurs first.
Phase 2: To evaluate secondary efficacy endpoints using the study treatment in selected populations 22 months Overall Survival (OS)
Phase 2: To evaluate the pharmacokinetics (PK) of study treatments by measuring blood plasma MRTX849 and potential metabolite concentrations. 22 months Pharmacokinetics (PK) Blood plasma Adagrasib and potential metabolite concentrations
Phase 3: To evaluate the PK of adagrasib administered in the study population 36 months Pharmacokinetics (PK) Blood plasma Adagrasib and potential metabolite concentrations
Phase 3: To evaluate health-related quality of life (HRQOL) and lung cancer specific symptoms in the study population 36 months Patient Reported Outcomes to measure quality of life
Phase 3: Progression Free Survival per RECIST 1.1 by Investigator 36 months Defined as time from first study treatment until disease progression or death from any cause, whichever occurs first.
Phase 3: Objective Response Rate (ORR) per RECIST 1.1 by Investigator and BICR 36 months Defined as the percent of patients documented to have a confirmed CR or PR.
Phase 3: Duration of Response (DOR) per RECIST 1.1 by Investigator and BICR 36 months Defined as the time from date of the first documentation of objective tumor response (CR or PR) to the first documentation of either Progression of Disease (PD) or death due to any cause, whichever occurs first.
Phase 3: To evaluate the safety and tolerability in the study population 36 months Safety characterized by type, incidence, severity, timing, seriousness and relationship to study treatment of adverse events and laboratory abnormalities.
Trial Locations
- Locations (524)
USOR - Texas Oncology - Dallas Fort Worth (DFW) - South Austin
🇺🇸Austin, Texas, United States
USOR - Texas Oncology - Dallas Fort Worth (DFW) - Odessa West Texas Cancer Center
🇺🇸Odessa, Texas, United States
Canberra Hospital
🇦🇺Garran, Australia
Local Institution - 007-1578
🇮🇳New Delhi, India
Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia
🇮🇹Brescia, Italy
Catholic University of Korea St. Vincents Hospital
🇰🇷Suwon-Si, Korea, Republic of
Local Institution - 007-556-A
🇺🇸Goodyear, Arizona, United States
USOR - Arizona Oncology - Prescott Valley
🇺🇸Prescott Valley, Arizona, United States
Local Institution - 007-568-A
🇺🇸Safford, Arizona, United States
Local Institution - 007-568-B
🇺🇸Safford, Arizona, United States
Local Institution - 007-568-C
🇺🇸Safford, Arizona, United States
Local Institution - 007-568-D
🇺🇸Safford, Arizona, United States
Local Institution - 007-568-E
🇺🇸Safford, Arizona, United States
Arizona Clinical Research Center
🇺🇸Tucson, Arizona, United States
Highlands Oncology Group - Springdale
🇺🇸Springdale, Arkansas, United States
Providence - Saint Joseph Home Health - Anaheim
🇺🇸Anaheim, California, United States
TOI Clinical Research (ICIR)
🇺🇸Cerritos, California, United States
Local Institution - 007-777
🇺🇸Fountain Valley, California, United States
Local Institution - 007-778
🇺🇸Laguna Hills, California, United States
Local Institution - 007-898-B
🇺🇸Long Beach, California, United States
MemorialCare - Long Beach Medical Center
🇺🇸Long Beach, California, United States
TRIO - Cancer and Blood Specialty Clinic
🇺🇸Los Alamitos, California, United States
Local Institution - 007-579
🇺🇸Los Angeles, California, United States
Local Institution - Unk045
🇺🇸Rancho Mirage, California, United States
San Francisco Veterans Affairs Medical Center
🇺🇸San Francisco, California, United States
UCSF Helen Diller Family Comprehensive Cancer Center
🇺🇸San Francisco, California, United States
Local Institution - 007-898-C
🇺🇸Santa Ana, California, United States
Providence Medical Group - Santa Rosa
🇺🇸Santa Rosa, California, United States
Stockton Hematology Oncology Medical Group (SHOMG) - Stockton (Suite B)
🇺🇸Stockton, California, United States
Local Institution - 007-898-A
🇺🇸Whittier, California, United States
Local Institution - 007-872-H
🇺🇸Aurora, Colorado, United States
Local Institution - 007-872-D
🇺🇸Boulder, Colorado, United States
Local Institution - 007-872-L
🇺🇸Centennial, Colorado, United States
Local Institution - 007-872-C
🇺🇸Colorado Springs, Colorado, United States
Local Institution - 007-872-K
🇺🇸Colorado Springs, Colorado, United States
Local Institution - 007-872-E
🇺🇸Denver, Colorado, United States
Local Institution - 007-872-I
🇺🇸Denver, Colorado, United States
Local Institution - 007-872-A
🇺🇸Lakewood, Colorado, United States
Local Institution - 007-872-J
🇺🇸Littleton, Colorado, United States
USOR - Rocky Mountain Cancer Centers - Lone Tree
🇺🇸Lone Tree, Colorado, United States
Local Institution - 007-872-G
🇺🇸Longmont, Colorado, United States
Local Institution - 007-872-B
🇺🇸Pueblo, Colorado, United States
Local Institution - 007-872-F
🇺🇸Thornton, Colorado, United States
Eastern Connecticut Hematology and Oncology Associates
🇺🇸Norwich, Connecticut, United States
Local Institution - 007-5476
🇺🇸Washington, District of Columbia, United States
GenesisCare USA
🇺🇸Aventura, Florida, United States
Bay Pines Veterans Affairs Healthcare System
🇺🇸Bay Pines, Florida, United States
Local Institution - 007-922-A
🇺🇸Bonita Springs, Florida, United States
Local Institution - 007-922-D
🇺🇸Bradenton, Florida, United States
Local Institution - 007-922-E
🇺🇸Cape Coral, Florida, United States
Local Institution - 007-896-A
🇺🇸Celebration, Florida, United States
Local Institution - 007-926-B
🇺🇸Daytona Beach, Florida, United States
Local Institution - 007-562-B
🇺🇸Fleming Island, Florida, United States
SCRI - Florida Cancer Specialists - South Region Research Office
🇺🇸Fort Myers, Florida, United States
Local Institution - 007-922-B
🇺🇸Fort Myers, Florida, United States
Local Institution - 007-922-C
🇺🇸Fort Myers, Florida, United States
Local Institution - 007-562-F
🇺🇸Jacksonville Beach, Florida, United States
21st Century Oncology of Jacksonville - North Lee Street
🇺🇸Jacksonville, Florida, United States
Local Institution - 007-562-D
🇺🇸Jacksonville, Florida, United States
Local Institution - 007-562-E
🇺🇸Jacksonville, Florida, United States
Local Institution - 007-562-G
🇺🇸Jacksonville, Florida, United States
Local Institution - 007-829
🇺🇸Jacksonville, Florida, United States
Cancer Specialists of North Florida - Southpoint
🇺🇸Jacksonville, Florida, United States
Local Institution - 007-562-C
🇺🇸Jacksonville, Florida, United States
Miami Veterans Affairs Healthcare System
🇺🇸Miami, Florida, United States
Local Institution - 007-922-F
🇺🇸Naples, Florida, United States
Local Institution - 007-922-G
🇺🇸Naples, Florida, United States
AdventHealth Orlando
🇺🇸Orlando, Florida, United States
USOR - Woodlands Medical Specialists
🇺🇸Pensacola, Florida, United States
Local Institution - 007-922-H
🇺🇸Port Charlotte, Florida, United States
Local Institution - 007-562-A
🇺🇸Saint Augustine, Florida, United States
Local Institution - 007-922-I
🇺🇸Sarasota, Florida, United States
Local Institution - 007-922-J
🇺🇸Sarasota, Florida, United States
Local Institution - 007-926-D
🇺🇸Stuart, Florida, United States
Local Institution - 007-924-A
🇺🇸Tallahassee, Florida, United States
SCRI - Florida Cancer Specialists - Tallahassee Cancer Center
🇺🇸Tallahassee, Florida, United States
James A. Haley Veterans Hospital
🇺🇸Tampa, Florida, United States
Local Institution - Unk065
🇺🇸Tampa, Florida, United States
Local Institution - 007-922-L
🇺🇸Venice, Florida, United States
Local Institution - 007-922-K
🇺🇸Venice, Florida, United States
Local Institution - 007-926-C
🇺🇸Vero Beach, Florida, United States
Local Institution - 007-926-A
🇺🇸Wellington, Florida, United States
SCRI - Florida Cancer Specialists - West Palm Beach
🇺🇸West Palm Beach, Florida, United States
Local Institution - Unk072
🇺🇸Weston, Florida, United States
University Cancer & Blood Center (UCBC) - Athens
🇺🇸Athens, Georgia, United States
Local Institution - Unk052
🇺🇸Atlanta, Georgia, United States
Local Institution - 007-786-C
🇺🇸Carrollton, Georgia, United States
Local Institution - 007-786-A
🇺🇸Cartersville, Georgia, United States
Local Institution - 007-786-D
🇺🇸Douglasville, Georgia, United States
Local Institution - 007-786-B
🇺🇸Hiram, Georgia, United States
Northwest Georgia Oncology Centers Wellstar - Marietta
🇺🇸Marietta, Georgia, United States
Local Institution - 007-897
🇺🇸Honolulu, Hawaii, United States
Local Institution - Unk005
🇺🇸Honolulu, Hawaii, United States
Local Institution - 007-883-A
🇺🇸Arlington Heights, Illinois, United States
Local Institution - 007-955
🇺🇸Chicago, Illinois, United States
University of Chicago
🇺🇸Chicago, Illinois, United States
Local Institution - 007-064
🇺🇸Maywood, Illinois, United States
USOR - Illinois Cancer Specialists - Niles
🇺🇸Niles, Illinois, United States
Advocate Medical Group Oncology
🇺🇸Park Ridge, Illinois, United States
Local Institution - Unk061
🇺🇸Peoria, Illinois, United States
Goshen Center for Cancer Care
🇺🇸Goshen, Indiana, United States
Local Institution - 007-942-B
🇺🇸Chanute, Kansas, United States
Local Institution - 007-942-D
🇺🇸El Dorado, Kansas, United States
Local Institution - 007-942-E
🇺🇸Independence, Kansas, United States
Local Institution - 007-942-F
🇺🇸Kingman, Kansas, United States
Local Institution - 007-942-G
🇺🇸Liberal, Kansas, United States
Local Institution - 007-942-H
🇺🇸McPherson, Kansas, United States
Local Institution - 007-5484
🇺🇸Merriam, Kansas, United States
Local Institution - 007-942-I
🇺🇸Newton, Kansas, United States
Local Institution - 007-942-J
🇺🇸Parsons, Kansas, United States
Local Institution - 007-942-K
🇺🇸Pratt, Kansas, United States
Local Institution - 007-942-L
🇺🇸Salina, Kansas, United States
Local Institution - 007-942-M
🇺🇸Wellington, Kansas, United States
Local Institution - Unk032
🇺🇸Westwood, Kansas, United States
Local Institution - 007-942-A
🇺🇸Wichita, Kansas, United States
Cancer Center of Kansas - Wichita - Heritage Plaza
🇺🇸Wichita, Kansas, United States
Local Institution - 007-942-N
🇺🇸Winfield, Kansas, United States
Lexington Medical Cancer Center Hematology/Oncology
🇺🇸Lexington, Kentucky, United States
University of Louisville
🇺🇸Louisville, Kentucky, United States
Local Institution - 007-388-A
🇺🇸Louisville, Kentucky, United States
Local Institution - Unk011
🇺🇸Baton Rouge, Louisiana, United States
Local Institution - 007-994-A
🇺🇸Covington, Louisiana, United States
Pontchartrain Cancer Center - Covington Office
🇺🇸Covington, Louisiana, United States
The Sidney Kimmel Comprehensive Cancer Center
🇺🇸Baltimore, Maryland, United States
Dana-Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
Dana-Farber Cancer Institute at St. Elizabeths Medical Center
🇺🇸Brighton, Massachusetts, United States
Brigham and Womens/Mass General Health Care Center at Foxborough
🇺🇸Foxboro, Massachusetts, United States
Dana-Farber Cancer Institute - Merrimack Valley
🇺🇸Methuen, Massachusetts, United States
Dana-Farber Brigham and Womens Cancer Center at Milford Regional
🇺🇸Milford, Massachusetts, United States
USOR - Minnesota Oncology - Burnsville
🇺🇸Burnsville, Minnesota, United States
Local Institution - 007-589A
🇺🇸Edina, Minnesota, United States
Local Institution - Unk006
🇺🇸Minneapolis, Minnesota, United States
Local Institution - 007-822
🇺🇸Minneapolis, Minnesota, United States
Local Institution - 007-830
🇺🇸Rochester, Minnesota, United States
Jackson Oncology Associates - The Hederman Cancer Center
🇺🇸Jackson, Mississippi, United States
Local Institution - 007-590D
🇺🇸Grand Island, Nebraska, United States
Local Institution - 007-590A
🇺🇸Omaha, Nebraska, United States
Local Institution - 007-590B
🇺🇸Omaha, Nebraska, United States
Nebraska Cancer Specialists - Midwest Cancer Center - Legacy
🇺🇸Omaha, Nebraska, United States
Local Institution - 007-590C
🇺🇸Papillion, Nebraska, United States
OptumCare Nevada
🇺🇸Las Vegas, Nevada, United States
Local Institution - 007-938A
🇺🇸Las Vegas, Nevada, United States
Local Institution - 007-938B
🇺🇸Las Vegas, Nevada, United States
Local Institution - 007-993
🇺🇸Belleville, New Jersey, United States
Astera Cancer Care - East Brunswick
🇺🇸East Brunswick, New Jersey, United States
John Theurer Cancer Center
🇺🇸Hackensack, New Jersey, United States
Local Institution - 007-975-A
🇺🇸Somerset, New Jersey, United States
Local Institution - 007-975-B
🇺🇸Somerset, New Jersey, United States
Local Institution - 007-975-C
🇺🇸Somerset, New Jersey, United States
Local Institution - 007-975-D
🇺🇸Somerset, New Jersey, United States
Holy Name Medical Center
🇺🇸Teaneck, New Jersey, United States
New York Oncology Hematology - Albany Medical Center
🇺🇸Albany, New York, United States
Montefiore Medical Center
🇺🇸Bronx, New York, United States
Local Institution - Unk077
🇺🇸Rhinebeck, New York, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Local Institution - 007-893-B
🇺🇸Cincinnati, Ohio, United States
USOR - Oncology Hematology Care - Blue Ash
🇺🇸Cincinnati, Ohio, United States
Local Institution - 007-893-C
🇺🇸Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
Mark H. Zangmeister Cancer Center
🇺🇸Columbus, Ohio, United States
Local Institution - 007-893-A
🇺🇸Fairfield, Ohio, United States
Kettering Health Cancer Center - Main Campus
🇺🇸Kettering, Ohio, United States
USOR - Willamette Valley Cancer Institute and Research Center - Eugene
🇺🇸Eugene, Oregon, United States
Local Institution - 007-885B
🇺🇸Portland, Oregon, United States
Local Institution - 007-885A
🇺🇸Portland, Oregon, United States
Oregon Oncology Specialists
🇺🇸Salem, Oregon, United States
Local Institution - 007-885C
🇺🇸Tigard, Oregon, United States
Local Institution - Unk041
🇺🇸Allentown, Pennsylvania, United States
Local Institution - 007-5477
🇺🇸Pittsburgh, Pennsylvania, United States
Local Institution - 007-960
🇺🇸Providence, Rhode Island, United States
Local Institution - Unk038
🇺🇸Charleston, South Carolina, United States
Local Institution - 007-5475
🇺🇸Spartanburg, South Carolina, United States
Avera Cancer Institute
🇺🇸Sioux Falls, South Dakota, United States
Local Institution - 007-928-L
🇺🇸Dickson, Tennessee, United States
Local Institution - 007-928-J
🇺🇸Franklin, Tennessee, United States
Local Institution - 007-928-G
🇺🇸Gallatin, Tennessee, United States
West Cancer Center & Research Institute - East Campus
🇺🇸Germantown, Tennessee, United States
Local Institution - 007-928-A
🇺🇸Hendersonville, Tennessee, United States
Local Institution - 007-928-D
🇺🇸Hermitage, Tennessee, United States
Local Institution - 007-928-H
🇺🇸Lebanon, Tennessee, United States
Local Institution - 007-928-F
🇺🇸Murfreesboro, Tennessee, United States
Local Institution - 007-928-B
🇺🇸Nashville, Tennessee, United States
Tennessee Oncology - Nashville - Centennial Clinic - Medical Oncology
🇺🇸Nashville, Tennessee, United States
Local Institution - 007-928-K
🇺🇸Nashville, Tennessee, United States
Local Institution - 007-928-E
🇺🇸Nashville, Tennessee, United States
Local Institution - 007-928-C
🇺🇸Nashville, Tennessee, United States
Local Institution - 007-928-M
🇺🇸Shelbyville, Tennessee, United States
Local Institution - 007-928-I
🇺🇸Smyrna, Tennessee, United States
Local Institution - 007-554B
🇺🇸Abilene, Texas, United States
Local Institution - 007-554G
🇺🇸Amarillo, Texas, United States
Local Institution - 007-879-A
🇺🇸Arlington, Texas, United States
Local Institution - 007-879-B
🇺🇸Arlington, Texas, United States
Local Institution - 007-892-B
🇺🇸Austin, Texas, United States
Local Institution - 007-892-A
🇺🇸Austin, Texas, United States
Local Institution - 007-879-C
🇺🇸Bedford, Texas, United States
Local Institution - Unk059
🇺🇸Dallas, Texas, United States
Local Institution - 007-592
🇺🇸Dallas, Texas, United States
Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center
🇺🇸Dallas, Texas, United States
USOR - Texas Oncology Northeast Texas - Denison
🇺🇸Denison, Texas, United States
Local Institution - 007-554E
🇺🇸El Paso, Texas, United States
Local Institution - 007-554C
🇺🇸El Paso, Texas, United States
Local Institution - 007-554F
🇺🇸El Paso, Texas, United States
USOR - Texas Oncology - Fredericksburg
🇺🇸Fredericksburg, Texas, United States
Local Institution - 007-848
🇺🇸Houston, Texas, United States
Local Institution - 007-999
🇺🇸Irving, Texas, United States
Local Institution - 007-890-B
🇺🇸Longview, Texas, United States
Local Institution - 007-554A
🇺🇸Midland, Texas, United States
USOR - Texas Oncology - The Woodlands
🇺🇸The Woodlands, Texas, United States
Local Institution - 007-890-A
🇺🇸Tyler, Texas, United States
Local Institution - 007-554D
🇺🇸Wichita Falls, Texas, United States
Local Institution - 007-912
🇺🇸Salt Lake City, Utah, United States
Local Institution - 007-814-A
🇺🇸Alexandria, Virginia, United States
Local Institution - 007-814-D
🇺🇸Arlington, Virginia, United States
USOR - Virginia Cancer Specialists - Fairfax Office
🇺🇸Fairfax, Virginia, United States
Local Institution - 007-814-B
🇺🇸Gainesville, Virginia, United States
Local Institution - 007-814-C
🇺🇸Leesburg, Virginia, United States
Virginia Cancer Institute - West End
🇺🇸Richmond, Virginia, United States
USOR - Northwest Cancer Specialists, P.C. dba Compass Oncology - Vancouver Cancer Center
🇺🇸Vancouver, Washington, United States
Local Institution - Unk064
🇺🇸Huntington, West Virginia, United States
Local Institution - Unk057
🇺🇸Madison, Wisconsin, United States
Local Institution - Unk068
🇺🇸Madison, Wisconsin, United States
Local Institution - Unk043
🇦🇷Ciudad Autonoma De Buenos Aires, Buenos Aires, Argentina
Local Institution - Unk053
🇦🇷Buenos Aires, Argentina
Local Institution - Unk033
🇦🇷Porto Alegre, Argentina
Local Institution - Unk020
🇦🇷Rio Cuarto, Argentina
Ballarat Regional Integrated Cancer Center
🇦🇺Ballarat, Australia
Flinders Medical Centre
🇦🇺Bedford Park, Australia
Local Institution - 007-004
🇦🇺Clayton, Australia
Cancer Care Wollongong
🇦🇺Wollongong, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Australia
Klinikum Klagenfurt Am Worthersee
🇦🇹Klagenfurt Am Woerthersee, Austria
Ordensklinikum Linz Elisabethinen
🇦🇹Linz, Austria
Wiener Gesundheitsverbund - Klinik Floridsdorf
🇦🇹Wien, Austria
Universitair Ziekenhuis Antwerpen
🇧🇪Edegem, Belgium
Algemeen Ziekenhuis Maria Middelares
🇧🇪Gent, Belgium
Jessa Ziekenhuis - Campus Virga Jesse
🇧🇪Hasselt, Belgium
Local Institution - 007-152
🇧🇪Roeselare, Belgium
Local Institution - Unk050
🇧🇷Lajeado, Rio Grande Do Sul, Brazil
Local Institution - Unk015
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Local Institution - Unk060
🇧🇷Barretos, Brazil
Local Institution - Unk002
🇧🇷Ijui, Brazil
Local Institution - Unk003
🇧🇷Rio de Janeiro, Brazil
Local Institution - Unk019
🇧🇷Sao Jose Do Rio Preto, Brazil
Local Institution - Unk074
🇧🇷Sao Paolo, Brazil
Multiprofile Hospital For Active Treatment - Dr. Tota Venkova
🇧🇬Gabrovo, Bulgaria
Specialized Hospital for Active Oncology Treatment - Haskovo SLLC (SBALO - Haskovo - EOOD)
🇧🇬Haskovo, Bulgaria
Complex Oncology Center - Plovdiv - Base II
🇧🇬Plovdiv, Bulgaria
University Multiprofile Hospital for Active Treatment St. Ivan Rilski
🇧🇬Sofia, Bulgaria
Complex Oncology Center - Vratsa
🇧🇬Vratsa, Bulgaria
Cross Cancer Institute
🇨🇦Edmonton, Alberta, Canada
British Columbia Cancer Agency - Vancouver
🇨🇦Vancouver, British Columbia, Canada
Local Institution - 007-489
🇨🇦London, Ontario, Canada
Ottawa Hospital - General Campus
🇨🇦Ottawa, Ontario, Canada
Princess Margaret Cancer Centre
🇨🇦Toronto, Ontario, Canada
Local Institution - 007-490
🇨🇦Montreal, Quebec, Canada
Local Institution - Unk028
🇨🇱Santiago, Chile
Local Institution - Unk073
🇨🇱Temuco, Chile
Local Institution - Unk021
🇨🇴Medellin, Colombia
Local Institution - Unk027
🇨🇴Monteria, Colombia
Local Institution - 007-4000
ðŸ‡ðŸ‡·Pula, Croatia
Local Institution - 007-4001
ðŸ‡ðŸ‡·Rijeka, Croatia
Local Institution - 007-4002
ðŸ‡ðŸ‡·Zagreb, Croatia
Multiscan - Ambulance klinicke onkologie se stacionarem - Horovice
🇨🇿Horovice, Czechia
Fakultni Nemocnice Olomouc
🇨🇿Olomouc, Czechia
Nemocnice AGEL Ostrava-Vitkovice
🇨🇿Ostrava, Czechia
Local Institution - 007-163
🇨🇿Praha 2, Czechia
Fakultni nemocnice Bulovka
🇨🇿Praha 8 - Liben, Czechia
Local Institution - 007-172
🇩🇰Odense, Denmark
Local Institution - 007-173
🇩🇰Soenderborg, Denmark
Local Institution - 007-170
🇩🇰Vejle, Denmark
Local Institution - 007-182
🇫🇮Tampere, Finland
Local Institution - 007-194
🇫🇷Brest, France
Local Institution - 007-190
🇫🇷Creteil, France
Local Institution - 007-683
🇫🇷La Tronche, France
Local Institution - 007-199
🇫🇷Marseille, France
Local Institution - 007-200
🇫🇷Montpellier, France
Local Institution - 007-666
🇫🇷Mulhouse, France
Local Institution - 007-664
🇫🇷Paris cedex 05, France
Local Institution - 007-198
🇫🇷Saint Herblain, France
Local Institution - 007-684
🇫🇷Strasbourg cedex, France
Local Institution - 007-209
🇫🇷Tours Cedex 9, France
Local Institution - 007-202
🇫🇷Villejuif, France
Local Institution - 007-790
🇬🇪Batumi, Georgia
Local Institution - 007-065
🇬🇪Tbilisi, Georgia
Local Institution - 007-795
🇬🇪Tbilisi, Georgia
Local Institution - 007-789
🇬🇪Tbilisi, Georgia
Local Institution - 007-063
🇬🇪Tbilisi, Georgia
Local Institution - 007-211A
🇩🇪Immenstadt, Bayern, Germany
Local Institution - 007-2215
🇩🇪Chemnitz, Germany
Klinikum Esslingen
🇩🇪Esslingen, Germany
Krankenhaus Nordwest
🇩🇪Frankfurt am Main, Germany
Universitatsklinikum Gieen und Marburg - Gieen
🇩🇪Giessen, Germany
LungenClinic Grosshansdorf
🇩🇪Grohansdorf, Germany
Local Institution - 007-677
🇩🇪Heidelberg, Germany
Local Institution - 007-673
🇩🇪Heilbronn, Germany
Lungenklinik Hemer
🇩🇪Hemer, Germany
Local Institution - 007-225
🇩🇪Jena, Germany
Klinikum Kassel
🇩🇪Kassel, Germany
Klinikverbund Allgau - Klinikum Kempten
🇩🇪Kempten, Germany
Local Institution - 007-2217
🇩🇪Koln, Germany
Universitatsklinikum Schleswig-Holstein - Campus Lubeck
🇩🇪Lubeck, Germany
Local Institution - 007-223
🇩🇪Mainz, Germany
Munchen Klinik Bogenhausen
🇩🇪Munchen, Germany
Sana Klinikum Offenbach
🇩🇪Offenbach, Germany
Pius-Hospital Oldenburg
🇩🇪Oldenburg, Germany
Local Institution - 007-502
🇬🇷Athens, Attiki, Greece
Local Institution - 007-236
🇬🇷Athens, Greece
Local Institution - 007-238
🇬🇷Heraklion, Greece
Local Institution - 007-235
🇬🇷Larissa, Greece
Local Institution - 007-234
🇬🇷Peiraias, Greece
Local Institution - 007-044
ðŸ‡ðŸ‡°Chai Wan, Hong Kong
Local Institution - 007-041
ðŸ‡ðŸ‡°Hong Kong, Hong Kong
Local Institution - 007-045
ðŸ‡ðŸ‡°Kowloon, Hong Kong
Semmelweis Egyetem - Pulmonologiai Klinika
ðŸ‡ðŸ‡ºBudapest, Hungary
Orszagos Koranyi Pulmonologiai Intezet
ðŸ‡ðŸ‡ºBudapest, Hungary
Orszagos Onkologiai Intezet
ðŸ‡ðŸ‡ºBudapest, Hungary
Farkasgyepui Tudogyogyintezet
ðŸ‡ðŸ‡ºFarkasgyepu, Hungary
Matrai Gyogyintezet
ðŸ‡ðŸ‡ºGyongyos, Hungary
Local Institution - 007-057
ðŸ‡ðŸ‡ºTatabanya, Hungary
Reformatus Pulmonologiai Centrum
ðŸ‡ðŸ‡ºTorokbalint, Hungary
Local Institution - 007-1568
🇮🇳Ahemdabad, India
Local Institution - 007-1574
🇮🇳Ahmedabad, India
Local Institution - 007-1565
🇮🇳Aurangabad, India
Local Institution - 007-1575
🇮🇳Belagavi, India
Local Institution - 007-1564
🇮🇳Hyderabad, India
Local Institution - 007-1563
🇮🇳Hyderabad, India
Local Institution - 007-1569
🇮🇳Jaipur, India
Local Institution - 007-1566
🇮🇳Kochi, India
Local Institution - 007-1570
🇮🇳Kolkata, India
Local Institution - 007-1573
🇮🇳Madurai, India
Local Institution - Shetty, R.
🇮🇳Mangalore, India
Local Institution - 007-1561
🇮🇳Mysore, India
Local Institution - 007-1567
🇮🇳New Delhi, India
Local Institution - 007-1560
🇮🇳Patna, India
Local Institution - 007-1571
🇮🇳Pune, India
Local Institution - 007-1562
🇮🇳Rajkot, India
Local Institution - 007-256
🇮🇪Cork, Ireland
Beaumont Hospital - Dublin
🇮🇪Dublin, Ireland
St. Jamess Hospital
🇮🇪Dublin, Ireland
Local Institution - 007-251
🇮🇪Dublin, Ireland
Local Institution - 007-257
🇮🇪Galway, Ireland
Local Institution - 007-258
🇮🇪Limerick, Ireland
University Hospital Waterford
🇮🇪Waterford, Ireland
Emek Medical Center
🇮🇱Afula, Israel
Rambam Health Care Campus
🇮🇱Bat Galim, Israel
Soroka Medical Center
🇮🇱Beer Sheva, Israel
Local Institution - 007-263
🇮🇱Holon, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Hadassah University Hospital Ein Kerem
🇮🇱Jerusalem, Israel
Kaplan Medical Center
🇮🇱Rehovot, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Ziv Medical Center
🇮🇱Zsfat, Israel
Local Institution - Unk016
🇮🇹Aviano, Italy
Istituto Tumori Bari Giovanni Paolo II - IRCCS
🇮🇹Bari, Italy
Azienda Ospedaliero-Universitaria di Bologna - Policlinico Sant Orsola-Malpighi
🇮🇹Bologna, Italy
Local Institution - 007-286
🇮🇹Candiolo, Italy
Azienda Ospedaliero - Universitaria Careggi
🇮🇹Firenze, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale Policlinico San Martino
🇮🇹Genova, Italy
"Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST"
🇮🇹Meldola, Italy
Local Institution - 007-283
🇮🇹Milano, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele
🇮🇹Milan, Italy
Istituto Europeo di Oncologia
🇮🇹Milan, Italy
Local Institution - 007-318
🇮🇹Monza, Italy
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
🇮🇹Napoli, Italy
Local Institution - Unk017
🇮🇹Padova, Italy
Azienda Ospedaliero-Universitaria di Parma
🇮🇹Parma, Italy
Local Institution - 007-281
🇮🇹Perugia, Italy
Azienda Sanitaria Territoriale Pesaro Urbino
🇮🇹Pesaro, Italy
Local Institution - 007-767
🇮🇹Ravenna, Italy
Istituto Nazionale Tumori Regina Elena
🇮🇹Roma, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
🇮🇹Roma, Italy
Local Institution - Unk030
🇮🇹Rozzano, Italy
Ospedale di Circolo e Fondazione Macchi
🇮🇹Varese, Italy
Local Institution - 007-1169
🇯🇵Toon-shi, Ehime, Japan
Local Institution - Hattori, Y.
🇯🇵Akashi City, Hyogo, Japan
Local Institution - Naoki, K.
🇯🇵Sagamihara, Kanagawa, Japan
Local Institution - 007-1159
🇯🇵Sendai, Miyagi, Japan
Local Institution - 007-1166
🇯🇵Kashihara, Nara, Japan
Local Institution - Okishio, K.
🇯🇵Sakai-Shi, Osaka, Japan
Local Institution - 007-1152
🇯🇵Fukushima-Shi, Japan
Local Institution - Kuyama, S.
🇯🇵Iwakuni, Japan
Local Institution - 007-1158
🇯🇵Nagoya, Japan
Local Institution - 007-1154
🇯🇵Nagoya, Japan
Local Institution - Daga, H.
🇯🇵Osaka, Japan
Local Institution - 007-1167
🇯🇵Osaka, Japan
Local Institution - 007-1164
🇯🇵Toyama, Japan
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Chungbuk National University Hospital
🇰🇷Cheongju-si, Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷Daegu, Korea, Republic of
National Cancer Center - Korea
🇰🇷Goyang-si, Korea, Republic of
Inha University Hospital
🇰🇷Jung-Gu, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Local Institution - 007-523
🇰🇷Seoul, Korea, Republic of
Local Institution - Unk079
🇲🇾Johor Bahru, Johor, Malaysia
Local Institution - Choo Khoon, O.
🇲🇾George Town, Penang, Malaysia
Local Institution - Unk048
🇲🇾George Town, Penang, Malaysia
Local Institution - Unk007
🇲🇾Petaling Jaya, Selangor, Malaysia
Local Institution - Unk075
🇲🇾Kuala Lumpur, Malaysia
Local Institution - Unk034
🇲🇽Mexico, Distrito Federal, Mexico
Local Institution - Unk049
🇲🇽Mexico, Distrito Federal, Mexico
Local Institution - Unk070
🇲🇽Guadalajara, Jalisco, Mexico
Local Institution - Unk037
🇲🇽Monterrey, Mexico
Local Institution - Unk026
🇲🇽Monterrey, Mexico
Het Nederlands Kanker Instituut
🇳🇱Amsterdam, Netherlands
Local Institution - 007-308
🇳🇱Den Haag, Netherlands
Local Institution - 007-633
🇳🇱Dordrecht, Netherlands
Ziekenhuis St Jansdal Harderwijk
🇳🇱Harderwijk, Netherlands
Local Institution - 007-630
🇳🇱Nijmegen, Netherlands
Erasmus Medisch Centrum
🇳🇱Rotterdam, Netherlands
Local Institution - 007-634
🇳🇱Rotterdam, Netherlands
Universitair Medisch Centrum Utrecht
🇳🇱Utrecht, Netherlands
Local Institution - 007-305
🇳🇱Zwolle, Netherlands
Local Institution - 007-310
🇳🇴Drammen, Norway
Local Institution - Unk080
🇵🇪Trujillo, La Libertad, Peru
Local Institution - Unk031
🇵🇪Cercado De Lima, Lima, Peru
Local Institution - Unk022
🇵🇪Jesus Maria, Lima, Peru
Local Institution - Unk024
🇵🇪Miraflores, Lima, Peru
Local Institution - Unk042
🇵🇪San Isidro, Lima, Peru
Local Institution - Unk071
🇵🇪San Isidro, Lima, Peru
Local Institution - Unk054
🇵🇪Surquillo, Lima, Peru
Local Institution - Unk051
🇵🇪Arequipa, Peru
Local Institution - Unk023
🇵🇪Arequipa, Peru
Local Institution - Unk044
🇵🇪Arequipa, Peru
Local Institution - Unk040
🇵🇪Cusco, Peru
Local Institution - Unk046
🇵🇪Lima, Peru
Local Institution - 007-1541
🇵ðŸ‡Bacolod City, Philippines
Local Institution - 007-1545
🇵ðŸ‡Cebu City, Philippines
Local Institution - 007-1544
🇵ðŸ‡Iloilo City, Philippines
Local Institution - 007-1543
🇵ðŸ‡Makati City, Philippines
Local Institution - 007-1542
🇵ðŸ‡Molo, Philippines
Local Institution - 007-1540
🇵ðŸ‡Quezon City, Philippines
Uniwersyteckie Centrum Kliniczne w Gdansku
🇵🇱Gdansk, Poland
Local Institution - 007-317
🇵🇱Kielce, Poland
Pratia MCM Krakow
🇵🇱Krakow, Poland
MS Pnuemed - Janusz Milanowski, Katarzyna Szmygin-Milanowska Spolka Jawna
🇵🇱Lublin, Poland
Local Institution - 007-059
🇵🇱Olsztyn, Poland
Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy
🇵🇱Otwock, Poland
Local Institution - 007-389
🇵🇱Poznan, Poland
Pratia Poznan
🇵🇱Skorzewo, Poland
Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu
🇵🇱Torun, Poland
Local Institution - 007-056
🇵🇱Warszawa, Poland
Local Institution - 007-322
🇵🇱Warszawa, Poland
Unidade Local de Saude de Coimbra
🇵🇹Coimbra, Portugal
Unidade Local de Saude do Alto Ave, E. P. E (Hospital da Senhora da Oliveira Guimaraes)
🇵🇹Guimaraes, Portugal
Local Institution - 007-338-A
🇵🇹Lisboa, Portugal
Local Institution - 007-642
🇵🇹Lisbon, Portugal
Hospital CUF Descobertas
🇵🇹Lisbon, Portugal
Local Institution - 007-334
🇵🇹Porto, Portugal
Unidade Local de Saude de Santo Antonio, E. P. E - Hospital Geral de Santo Antonio
🇵🇹Porto, Portugal
Local Institution - 007-339
🇵🇹Porto, Portugal
Local Institution - 007-335
🇵🇹Vila Nova de Gaia, Portugal
Local Institution - 007-340
🇷🇴Cluj-Napoca, Romania
Local Institution - 007-518
🇷🇴Floresti, Romania
Local Institution - 007-515
🇷🇴Timisoara, Romania
Local Institution - 007-693
🇷🇸Belgrade, Serbia
Local Institution - 007-694
🇷🇸Kragujevac, Serbia
Local Institution - 007-691
🇷🇸Sremska Kamenica, Serbia
Local Institution - 007-3515
🇷🇸Uzice, Serbia
Local Institution - 007-095
🇸🇬Singapore, Singapore
Local Institution - 007-4010
🇿🇦Port Elizabeth, Eastern Cape, South Africa
Local Institution - 007-4013
🇿🇦Johannesburg, Gauteng, South Africa
Local Institution - 007-4012
🇿🇦Pretoria, Gauteng, South Africa
Local Institution - 007-611 A
🇪🇸Pamplona, Navarre, Spain
Complejo Hospitalario Universitario A Coruna
🇪🇸A Coruna, Spain
Institut Catala dOncologia Badalona
🇪🇸Badalona, Spain
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital Universitari Dexeus
🇪🇸Barcelona, Spain
Hospital Universitari Vall dHebron
🇪🇸Barcelona, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Local Institution - Unk081
🇪🇸Bilbao, Spain
Local Institution - Unk063
🇪🇸Burgos, Spain
Local Institution - Unk014
🇪🇸Jerez de la Frontera, Spain
Local Institution - 007-628
🇪🇸Las Palmas de Gran Canaria, Spain
Local Institution - Unk012
🇪🇸Leon, Spain
Institut Catala dOncologia - Hospital Duran i Reynals (ICO LHospitalet)
🇪🇸LHospitalet de Llobregat, Spain
Clinica Universidad de Navarra - Madrid
🇪🇸Madrid, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Regional Universitario de Malaga - Hospital Civil
🇪🇸Malaga, Spain
Local Institution - 007-604
🇪🇸Santander, Spain
Hospital Clinico Universitario de Santiago
🇪🇸Santiago de Compostela, Spain
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Hospital Clinico Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Universitari i Politecnic La Fe
🇪🇸Valencia, Spain
Local Institution - Unk013
🇸🇪Gavle, Sweden
Local Institution - 007-397
🇨ðŸ‡Sankt Gallen, Switzerland
Local Institution - 007-396
🇨ðŸ‡Villars-sur-Glane, Switzerland
Local Institution - 007-128
🇨🇳Taichung City, Taiwan
Local Institution - 007-127
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
Chi Mei Hospital - Liouying
🇨🇳Tainan City, Taiwan
Local Institution - 007-122
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei City, Taiwan
Local Institution - 007-126
🇨🇳Taipei City, Taiwan
Local Institution - 007-129
🇨🇳Taipei City, Taiwan
Chang Gung Memorial Hospital - Linkou Branch
🇨🇳Taoyuan, Taiwan
Local Institution - 007-139
🇹ðŸ‡Bangkok, Thailand
Local Institution - Runglodvatana, Y.
🇹ðŸ‡Krung Thep Maha Nakhon, Thailand
Local Institution - 007-061
🇹🇷Alanya, Turkey
Local Institution - 007-096
🇹🇷Altindag, Turkey
Local Institution - 007-066
🇹🇷Ankara, Turkey
Local Institution - 007-3810
🇹🇷Antalya, Turkey
Local Institution - 007-098
🇹🇷Bahcelievler, Turkey
Local Institution - 007-060
🇹🇷Bornova, Turkey
Local Institution - 007-055
🇹🇷Cankaya, Turkey
Local Institution - 007-054
🇹🇷Edirne, Turkey
Local Institution - 007-069
🇹🇷Istanbul, Turkey
Local Institution - 007-099
🇹🇷Izmir, Turkey
Local Institution - 007-3811
🇹🇷Kocaeli, Turkey
Local Institution - 007-097
🇹🇷Malatya, Turkey
Local Institution - 007-068
🇹🇷Mamak, Turkey
Local Institution - 007-062
🇹🇷Sisli, Turkey
University Hospitals Birmingham NHS Foundation Trust
🇬🇧Birmingham, United Kingdom
Local Institution - 007-415
🇬🇧Edinburgh, United Kingdom
Local Institution - 007-403
🇬🇧Kent, United Kingdom
University Hospitals of Leicester NHS Trust
🇬🇧Leicester, United Kingdom
University College London Hospitals NHS Foundation Trust
🇬🇧London, United Kingdom
Guys and St Thomas NHS Foundation Trust
🇬🇧London, United Kingdom
The Christie NHS Foundation Trust
🇬🇧Manchester, United Kingdom
Royal Surrey County Hospital NHS Foundation Trust
🇬🇧Surrey, United Kingdom