The effect of a Procalcitonin guided algorithm compared with standard care on the number of antibiotic treatment days in critically ill intensive care patients with suspected infection

Prince of Wales Hospital0 个研究点目标入组 400 人开始时间: 2010年9月28日最近更新: 2020年1月13日

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•Patients will be eligible for inclusion in the study if they meet the following criteria;
•1. Antibiotic therapy is required for presumed infection
•2. Antibiotic therapy is required for > 24 hrs
•3. Anticipated stay in intensive care is for > 24 hours

•1.Age < 18 years old
•2.Antibiotics are prescribed for surgical prophylaxis only
•3.Suspected or proven isolated systemic fungal infection
•4.The patient is being treated with immunosuppressive agents (excluding steroids)
•5.The patient is neutropenic and receiving antimicrobial therapy
•6.Suspected or proven Mycobacterium Tuberculosis
•7. Antimicrobial therapy for proven bacterial infection requiring prolonged
•antibiotic therapy for > 3 weeks (e.g. proven bacterial endocarditis, proven
•bacterial meningitis, osteomyelitis, deep tissue infections)
•8. The patients is receiving treatment for an isolated systemic viral infection
•9. Cardiac surgery in the previous 48 hrs
•10. Admission to ICU for multi-trauma or burns
•11. Admission to ICU for environmental heatstroke
•12. Patients with malignancies that are known to raise PCT levels (such as small
•cell Carcinoma (Ca) of the Lung or C cell Ca of the Thyroid)
•13. The patient not expected to survive > 24 hrs
•14. The patient is receiving palliative care only, and is not expected to survive
•hospital discharge
•15. The patient is known to be pregnant.

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