Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve
Completed
- Conditions
- Aortic Valve Stenosis
- Registration Number
- NCT02727504
- Lead Sponsor
- Rennes University Hospital
- Brief Summary
Investigators sought to demonstrate that the increase in the stroke volume during a dobutamine stress echocardiography might impact the prognosis of a patient addressed for a low flow low gradient suspected severe aortic valve stenosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 86
Inclusion Criteria
- Patient from 45 to 90 years old
- Patient agreeing freely to participate in the study
- Aortic surface area suspected to be < 1 cm² or < 0.6 cms²/m²
- Low aortic gradient defined by a mean pressure gradient < 40 mmHg
- Aortic low flow defined by: a stroke volume indexed < 35 ml/m2
- Any contra-indication for the realization of the MRI
Exclusion Criteria
- Heart rhythm disorders
- Presence of comorbidity altering the 2-year prognosis of a patient (cancer, terminal renal insufficiency (GFR 30 ml / min / 1,73m2), liver cirrhosis, respiratory insufficiency (VEMS 1 L)
- Presence of a concomitant valvular heart disease with stenosis or regurgitation > moderated
- Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of death of all cause Month 12 Number of emergent hospitalization for any cardiovascular reason Month 12
- Secondary Outcome Measures
Name Time Method Death (all causes) 12 months Emergency Cardiovascular hospitalization 12 months Change in left ventricular ejection fraction (LVEF), in global longitudinal strain in 2D and or 3D echocardiography Inclusion, 12 months Symptoms evolution Inclusion, 12 months Duke Activity Score
Trial Locations
- Locations (1)
CHU de Rennes
🇫🇷Rennes, France
CHU de Rennes🇫🇷Rennes, France