Clinical Effectiveness and Microbiological Evaluation of a Mouthwash of Pomegranate (Punica Granatum Linn.) in School Children
Overview
- Phase
- Not Applicable
- Intervention
- Punica granatum Linn.
- Conditions
- Gingivitis
- Sponsor
- Universidade Estadual da Paraiba
- Enrollment
- 35
- Locations
- 1
- Primary Endpoint
- Difference in the Gingival Index scores.
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The mechanical control of supragingival biofilm is accepted as one of the most important measures to prevent dental caries and periodontal diseases. Nevertheless, maintaining dental surfaces biofilm-free is not an easy task. In this regard, numerous studies researches have demonstrated the effectiveness of mouthwashes containing antimicrobial active ingredients that prevent and control both supragingival biofilm and gingivitis, specially when used adjunctively to mechanical oral hygiene regimens.
Detailed Description
In vitro and clinical researches using Punica granatum Linn shows antimicrobial and antiadherent activity against dental biofilm microorganisms. The purpose of this study was to evaluate the clinical effectiveness of a mouthwash of Punica granatum Linn. against biofilm and gingival inflammation in school children
Investigators
DANÚBIA ROBERTA DE MEDEIROS NÓBREGA
Professor clinical
Universidade Estadual da Paraiba
Eligibility Criteria
Inclusion Criteria
- •Age group: 09-12 years old
- •Presence of at least 20 teeth
- •Simplified Oral Hygiene Index (S-OHI)≥ 1,6
Exclusion Criteria
- •Use of orthodontic appliance
- •Recent (in the past 2 months)use of antibiotics and mouthwashes
Arms & Interventions
Punica granatum Linn.
The childrens used the mouthwash contain pomegranate 6,25% twice daily for 14 days.
Intervention: Punica granatum Linn.
chlorhexidine
The childrens used the mouthwash contain chlorhexidine 0.12% twice daily for 14 days.
Intervention: chlorhexidine
Outcomes
Primary Outcomes
Difference in the Gingival Index scores.
Time Frame: Baseline, Seventh Day and Fourteeth day (14 days)
On day 0, we measured the Plaque Index (PI) (Silness; Löe, 1964) at baseline, on the seventh day and on the fourteenth day.
Difference in the Microbiological analysis of saliva for oral streptococcus count evolution from the start till the end of the study.
Time Frame: Baseline and Fourteeth day (14 days)
At baseline, we collected non-stimulated saliva samples into a sterile container for counting of oral streptococci in the laboratory. And on the fourteenth day, we carried out the second saliva collection and measured the clinical indices used.
Difference in the Gingival Bleeding Index scores.
Time Frame: Baseline, Seventh Day andFourteeth day (14 days)
On day 0, we measured the Bleeding on Probing Index (BPI) (Ainamo; Bay, 1975) at baseline, on the seventh day and on the fourteenth day.