Advancing Prevention of Pulmonary Fibrosis

Active, not recruiting

• Conditions: IPF; Pulmonary Fibrosis; ILD
• Interventions: Other: Sample collection; Other: Questionnaires; Radiation: High resolution CT scan of the chest; Diagnostic Test: Pulmonary Function Test

• Registration Number: NCT04564183
• Lead Sponsor: University of Colorado, Denver

Brief Summary

This study plans to learn more about pulmonary fibrosis and how it develops. We want to determine if the disease can be detected early, before the lung is permanently scarred.

This study will enroll participants who are not currently diagnosed with pulmonary fibrosis, but who have family members with pulmonary fibrosis. Because there is an increased risk within affected families, this cohort will allow us to learn how pulmonary fibrosis develops, and how the lungs change over time.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-09-18
• Study First Submitted QC: 2020-09-21
• Study First Posted: 2020-09-25
• Study Start: 2021-01-22
• Status Verified: 2024-10
• Primary Completion: 2024-10-01
• Last Update Submitted: 2024-10-07
• Last Update Posted: 2024-10-10
• Study Completion: 2026-08-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

• Unaffected first degree relative from Familial Interstitial Pneumonia families (two or more family members with IIP)
• Age at least 40 years old and younger than 75 years old

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Exclusion Criteria

• Diagnosed with known (physician-diagnosed) pulmonary fibrosis prior to informed consent
• Other genetic diseases associated with interstitial lung disease
• Pregnant women

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Full Cohort	Sample collection	Entire study population
Full Cohort	Questionnaires	Entire study population
Full Cohort	Pulmonary Function Test	Entire study population
Full Cohort	High resolution CT scan of the chest	Entire study population

Primary Outcome Measures

Name	Time	Method
Screen all subjects for early Idiopathic Pulmonary Fibrosis (IPF) with High Resolution CT Scan of the Chest	Baseline	All subjects will be screened with a high resolution CT scan to identify early signs of lung fibrosis. CT scans will be evaluated by study radiologists.

Trial Locations

Locations (1)

University of Colorado Anschutz Medical Campus; 🇺🇸 Aurora, Colorado, United States