The effect of noradrenaline infusion versus standard blood pressure management on perioperative HYPotension in NOncaRdiac surgery. - HYP-NOR

niwersytet Jagiellonski Collegium Medicum0 个研究点目标入组 750 人开始时间: 2024年3月26日最近更新: 2024年8月21日

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•=45years old, Elective or accelerated* for noncardiac surgery expected to last = 1 hour and requiring general, neuraxial, or combined general & neuraxial anaesthesia, Expected to require at least overnight hospital stay, Written informed consent to participate in the HYP-NOR Trial provided, American Society of Anesthesiologists (ASA) physical status class II or higher.

•Newly diagnosed, untreated, or uncontrolled hypertension -in two measurements on the day before surgery Systolic Blood Pressure (SBP) =180 mm Hg or Diastolic Blood Pressure (DBP) =110 mm Hg, Receiving irreversible nonselective monoamine oxidase inhibitors (e.g. tranylcypromine, phenelzine) within 2 weeks preceding study enrolment, Have contraindications to noradrenaline per clinician judgement, Noradrenaline infusion started before surgery or plan to use continuous noradrenaline infusion throughout the procedure, Treating physician (surgeon/anaesthetist) decides on the necessity of extended continuous hemodynamic monitoring during or after surgery, Severe kidney disease (MDRD creatinine clearance <15 mL/min/1.73m2) or renal replacement therapy, Persistent difference in recorded SBP between right and left upper limb >10 mm Hg, Persistent atrial fibrillation, End-stage heart failure, Known severe liver disease, Emergency and urgent surgery defined as performed within 24 hours of sudden illness/unplanned admission to hospital, Have previously participated in the trial, Pregnant or breastfeeding women, Have a documented history of dementia, Have language, vision, or hearing impairments that may compromise cognitive assessments, Have a condition that precludes routine blood pressure management such as surgeon request for relative hypotension

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niwersytet Jagiellonski Collegium Medicum