on-invasive assessment of skeletal muscle involvement in Duchenne muscular dystrophy

Completed

Conditions: Duchenne Muscular Dystrophy
10028302

Registration Number: NL-OMON39843

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Trial is onging in other countries

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 38

Inclusion Criteria

DMD patients of 8 years and older with typical muscle weakness and a known genetic mutation in the dystrophin gene.
Healthy boys of 8 years or older form the control group.

Exclusion Criteria

General exclusion criteria are:
- Claustrophobia
- Pacemakers and defibrillators
- Nerve stimulators
- Intracranial clips
- Intraorbital or intraocular metallic fragments
- Cochlear implants
- Ferromagnetic implants (e.g. thoracic implant for scoliosis)
- Inability to lie supine during less than 60 minutes;Exclusion criteria for healthy controls
- any muscle disease
- recent muscle trauma

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Quantitative assessment of pathological changes in skeletal muscle of DMD<br /><br>patients by assessment of:<br /><br>- the level of fatty infiltration<br /><br>- T2 relaxation parameters as a marker for muscle edema<br /><br>- individual muscle volume </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Variation of MR parameters between different muscles, or between different ages<br /><br>in DMD patients.<br /><br>Correlation of MR parameters with strength measurements.<br /><br>Differences of T2 relaxation parameters between steroid users and non-steroid<br /><br>users<br /><br>Explore the use of other MR muscle parameters like diffusion tensor imaging.</p><br>