Dead Space Evaluation During Exercise in Patients With Pulmonary Hypertension
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 18
- Primary Endpoint
- dead space ventilation (measured in L/min)
Study Overview
Brief Summary
Aim of the study is to evaluate the role of chemoreceptor activity and ventilation perfusion mismatch on the genesis of exercise induced hyperventilation in Pulmonary hypertension patients. So the investigators tested the chemoreceptor response at rest, both with hypoxic and hypercapnic stimuli, and the ventilatory response during exercise analyzing its two components, alveolar and dead space ventilation.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •age ≥18 and ≤ 80 years
- •ability to understand the research protocol and willing to sign the study informed consent
- •diagnosis of pulmonary arterial hypertension belonging to Class I and IV
- •stable haemodynamic status and optimized medical treatment since at least 2 months
- •ability to perform maximal cardiopulmonary exercise test and pulmonary diffusing capacity for carbon monoxide evaluation
Exclusion Criteria
- •relevant comorbidities
- •usual contraindications for cardiopulmonary exercise test
- •pulmonary hypertension associated to left heart and pulmonary disease, congenital heart diseases with evident cardiac shunts.
Arms & Interventions
Pulmonary hypertension patients
All Pulmonary hypertension patients enrolled in the study underwent a cardiopulmonary exercise test and hypoxia and hypercapnia tests
Intervention: cardiopulmonary exercise test,hypoxia and hypercapnia test (Other)
Outcomes
Primary Outcomes
dead space ventilation (measured in L/min)
Time Frame: 1 week
Dead space ventilation is calculated through the equation: VT\* \[1- (863\*VCO2)/(VE\*PaCO2)\], where VT = tidal volume, VCO2= CO2 output, VE= pulmonary ventilation,PaCO2 is the arterial partial pressure of CO2 and 863 is a constant.
Secondary Outcomes
- central hypercapnic chemosensitivity (measured in L/min/mmHg)(1 week)
- peripheral response to hypoxia (measured in L/min/O2)(1 week)
- peripheral response to hypercapnia (measured in L/min/mmHg)(1 week)
Investigators
Piergiuseppe Agostoni
Professor
Centro Cardiologico Monzino