Cardiopulmonary exercise testing before and after blood transfusio
- Conditions
- AnaemiaHaematological Disorders
- Registration Number
- ISRCTN27615323
- Lead Sponsor
- Royal Victoria Infirmary Newcastle (UK)
- Brief Summary
2014 results in https://www.ncbi.nlm.nih.gov/pubmed/24681715 (added 22/02/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 28
1. Patients requiring blood transfusion under the care of the haematology team
2. Patients over the age of 18 years
3. Capacity to give informed consent
4. Comprehension of English
5. Ability to undertake CPX testing using a cycle ergometer
1. A requirement to have an urgent blood transfusion as judged by the haematologist caring for the patient. (This would not allow sufficient time to undertake proper consent and perform CPX tests one and two).
2. Ongoing active bleeding
3. Those who get angina or intermittent claudication on moderate exercise or who have shortness of breath at rest
4. Patients who have a significant acute medical illness
5. Those with other contraindications to exercise testing according to the ACC/AHA Exercise Testing Guidelines or our own local guidelines
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The change in anaerobic threshold following blood transfusion
- Secondary Outcome Measures
Name Time Method <br> 1. The change in AT per unit (g/dL) change in Hb concentration will be determined to correct for the variable change in Hb seen with blood transfusion<br> 2. Changes in other CPX variables following transfusion, including peak VO2, OEUS (Oxygen Efficiency Utilisation Slope), Ve/VCO2 ratio, VO2/HR ratio and Respiratory Exchange Ratio (RER)<br> 3. Intra-patient variability in the AT measured by CPX testing will be expressed as the coefficient of variation<br>