The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm
- Registration Number
- NCT00538967
- Lead Sponsor
- Leiden University Medical Center
- Brief Summary
The matrix metalloproteinase-9 (MMP-9) is considered to play a central role in abdominal aortic aneurysm (AAA) initiation. Doxycycline has direct MMP-9 inhibiting properties in vitro, and it effectively suppresses AAA development in rodents. Observed inhibition of AAA progression, and contradictory findings in human studies evaluating the effect of doxycycline therapy on aortic wall MMP-9 suggest that the effects of doxycycline extend beyond MMP-9 inhibition, and that the effect may be dose dependent.
- Detailed Description
In this clinical trial, we evaluated the effect of two weeks of low (50 mg/day), medium (100 mg/day) or high dose (300 mg/day) doxycycline versus no medication in patients undergoing elective AAA repair. The effect of doxycycline treatment on MMP and cysteine proteases, and their respective inhibitors was evaluated in an integrative approach.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- Elective open aneurysm repair
- Severe kidney and liver dysfunction
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 4 doxycycline doxycycline 300 mg 2 doxycycline doxycycline 50 mg/day 3 doxycycline doxycycline 100 mg
- Primary Outcome Measures
Name Time Method Collagenase mRNA and protein expression 2 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Leiden University Medical Center
🇳🇱Leiden, Netherlands