NCT00756145已完成4 期
The Use of Low Molecular Weight Heparin in Hemodiafiltration
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Anti-Xa activity at the end of the session
研究概览
简要总结
Low molecular weight heparin (LMWH) is injected in the dialysis circuit at the start of the session. In the present study we compare 3 different methods of injection of LMWH: parameters of dialysis efficiency and clotting are measured. The study lasts 3 sessions for each patient.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic kidney disease stade V treated with hemodiafiltration
- •age >18 year
- •Hematocrit > 30%
排除标准
- •treatment with vitamin K antagonists
- •treatment with other anti-coagulants or heparin besides the heparin used during dialysis
- •active bleeding, infection or malignancy
- •heparin associated allergy
- •hepatic failure
- •trombocytopenia < 120.000/µl
结局指标
主要结局
Anti-Xa activity at the end of the session
时间窗: 240 min after start
次要结局
- Visual inspection of membrane and circuit(After the hemodiafiltration session)
- Reduction ratio of beta2microglobulin(after 10min, 180min and 240min)
- pressure measurements along the circuit(during the session)
- Anti-Xa activity during the session(at start, 30 min, 120 min and 180 min)
- ETP during the session(at start, 30 min, 120 min, 180 min and 240 min)
- Reduction ratio of urea(after 10min, 180min and 240min)
研究者
研究点 (2)
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