Oligodontia phenotypes and their genetic pathways component
Recruiting
- Conditions
- Missing of 6 or more teeth.
- Registration Number
- DRKS00027247
- Lead Sponsor
- Charité Zahnklinik
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Absence of six or more permanent teeth (excluding wisdom teeth)
Exclusion Criteria
Younger than 9 years
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. The aim of the study is to investigate the appearance of patients with oligodontia. For this purpose, the numerical code (Tooth Agenesis Code, TAC) will be used to establish the correlation between the genotype and the phenotype of phenotype of the nongenesis.<br>2. the genetic material of the patients and their family members (adult siblings, parents or grandparents) will be analyzed according to the genes identified by previous studies.<br>3. in addition, new genes responsible for hypo /oligodontia (hypodontia: not attachment of 1-5 teeth, oligodontia: 6 or more unattached teeth).<br>(hypodontia: 1-5 teeth not attached, oligodontia: 6 or more teeth not attached), using the whole genome sequencing method.<br>4. The purpose of the study is to standardize the diagnosis of patients with oligodontia.
- Secondary Outcome Measures
Name Time Method