Relationship and differences between Central Aortic and Peripheral Blood Pressure measurement performed with the same device.

Not yet recruiting

• Conditions: Essential (primary) hypertension,

• Registration Number: CTRI/2020/12/029750
• Lead Sponsor: Eris Lifesciences Ltd

Brief Summary

Accumulatingevidence indicates that central blood pressure (CBP) is a better cardiovascularrisk predictor than brachial blood pressure (BBP). Although more additionalbenefits of CBP based treatment above usual hypertension treatment are to bedemonstrated, the demand for implementing CBP assessment in general clinicalpractice is increasing. For this, the measurement procedure must be non-invasive,easy to perform, and cost- and time-efficient. Therefore, oscillometric deviceswith the possibility to assess CBP seem the best option

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-17
• Last Update Posted: 2023-07-08

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 1200

Inclusion Criteria

• Outpatients with hypertension (BP greater than 140/90 mm Hg or any level of blood pressure in persons on antihypertensive medications) 2.
• Newly Diagnosed Hypertensive Patients 3.
• Normotensive patients on antihypertensive 4.
• Hypertensive subjects with a family history of premature coronary heart disease 5.
• Hypertensive patients with comorbidities (Diabetes, Dyslipidaemia, CAD, left ventricular hypertrophy, peripheral arterial disease, cerebrovascular disease, microalbuminuria or proteinuria).

Exclusion Criteria

• Subjects with evidence of recent event (MI < 1-month duration, treated angina at the time of enrolment, a cerebrovascular event in the 3 months before enrolment, heart failure, uncontrolled arrhythmias, or any clinically important haematological or biochemical abnormality on routine screening) 2.
• In-patients/Hospitalized patients 3.
• Pregnant Women.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To establish correlation and differences between brachial blood pressure and central blood pressure so as to establish the cut-off values (threshold values) for central blood pressure based on the brachial blood pressure.	1 Year

Secondary Outcome Measures

Name	Time	Method
To establish the correlation between CBP and BBP with organ damage (LV hypertrophy, End-stage kidney disease etc)	1 Year

Trial Locations

Locations (7)

Apollo Hospital Enterprise Limited; 🇮🇳 Chennai, TAMIL NADU, India

Batra Hospital & Medical Research Centre; 🇮🇳 Delhi, DELHI, India

HERO DMC Heart Institute, Dayanand Medical College & Hospital; 🇮🇳 Ludhiana, PUNJAB, India

Jaipur Golden Hospital; 🇮🇳 West, DELHI, India

Kovai Medical Center and Hospital,; 🇮🇳 Coimbatore, TAMIL NADU, India

Laxmi Hospital; 🇮🇳 Palakkad, KERALA, India

Sir Ganga Ram Hospital; 🇮🇳 Delhi, DELHI, India

Apollo Hospital Enterprise Limited

🇮🇳Chennai, TAMIL NADU, India

Dr Abraham Oomman

Principal investigator

9841174578

drabrahamoomman@gmail.com