ChiCTR-IOR-17010484已完成不适用
保持 ICU 機械通氣危重病人四肢肌肉量
Self finance1 个研究点 分布在 1 个国家目标入组 98 人开始时间: 2015年10月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- Muscle thickness
研究概览
简要总结
The present study aimed to (1) examine the effect of early neuromuscular electrical stimulation (NMES) on quadriceps and biceps muscles size (in terms of thickness and cross sectional area) in patients who are mechanically ventilated in intensive care unit (ICU), and (2) elevate the quality of life and functional status of those patients receiving NMES at ICU discharge and (3) quantify the ICU length of stay, hospital length of stay and number of patients who were diagnosed with ICU acquired weakness at ICU discharge.
研究设计
- 研究类型
- 干预性研究
- 主要目的
- 随机平行对照
入排标准
- 年龄范围
- 18 至 —（—）
- 性别
- All
入选标准
- •Adult patients at ICU who are on mechanical ventilator due to acute respiratory failure, trauma, sepsis, and acute coronary syndromes;
- •Cardiorespiratory stability: FiO2≤ 55% & noradrenaline ≤ 0.2 ug/kg/min.
排除标准
- •Conditions contraindicated for NMES such as skin allergy, open wounds or superficial metal implants over stimulation sites, etc.;
- •Trauma or surgery of leg, pelvis, or lumbar spine;
- •Open abdominal wounds;
- •Extreme obesity (BMI > 35kg/m2);
- •Serious bedsore or venous ulcers;
- •Pre-existing diagnosis causing neuromuscular weakness;
- •Acute stroke, Status epilepticus;
- •Coagulation disorders (INR>1.5 or platelets < 50,000/mm3);
- •Psychiatric disorder or emotional instability;
- •Cardiorespiratory instability:
- •PaO2 <8.66kPa;
- •Minute ventilation >150mL/kg body weight;
- •Respiratory rate >30 BPM;
- •On vasopressive support (noradrenaline > 0.2μgkg-1.min-1, dobutamine > 8μg.kg-1.min-1).
- •Acute renal failure with increased serum creatinine level (normal result is 0.7 to 1.3 mg/dL for men and 0.6 to 1.1 mg/dL for women);
- •APACHE II score ≥ 30.
研究组 & 干预措施
1
肌肉電刺激
2
Nil
结局指标
主要结局
Muscle thickness
Muscle cross sectional area
次要结局
- quality of life
- FSS-ICU functional staus
研究者
研究点 (1)
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