Effects of Alpha Lipoic Acid Supplementation in G6PD Deficient Individuals After Acute Exercise
- Conditions
- G6PD Deficiency
- Registration Number
- NCT02937363
- Lead Sponsor
- University of Thessaly
- Brief Summary
The purpose of this study is to investigate the effects of alpha-lipoic acid supplementation on redox status, physiological and biochemical parameters in G6PD deficient individuals after acute exercise.
- Detailed Description
In a randomized double-blind, crossover design, 12 adult volunteers with G6PD deficiency of both sexes will be supplemented with either 600 mg of alpha-lipoic acid (experimental condition - EC) or placebo (control condition - CC) every day for 4 weeks. Before intervention, all participants will be informed about the study protocol, fill a medical history questionnaire and sign an informed consent form. Moreover, measurements of anthropometric characteristics and physiological parameters, as well as a VO2max test will be performed.
Participants will perform 4 trials of exercise (70% VO2max for 45min and 90% till exhaustion) before and after each condition. Blood samples will be collected before, immediately after and 1 hour after exercise. Moreover, measurements of anthropometric characteristics and physiological parameters will be performed before and after each condition. There will be a washout period of at 4 weeks between conditions.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- G6PD deficiency
- Any uncontrolled health condition for which exercise is contraindicated
- Current use of dietary supplements or drugs
- Pregnant, pregnancy intention or breast feeding
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Change in redox status after exercise Before, immediately after and 1 hour after each trial of exercise Indices of blood redox status
- Secondary Outcome Measures
Name Time Method Body composition Before and after 4 weeks of alpha-lipoic acid supplementation, before and after 4 weeks of placebo Body fat percentage
Blood pressure Before and after 4 weeks of alpha-lipoic acid supplementation, before and after 4 weeks of placebo Blood pressure at rest
Trial Locations
- Locations (1)
Department of Physical Education & Sport Science of the University of Thessaly
🇬🇷Trikala, Karyes, Greece
Department of Physical Education & Sport Science of the University of Thessaly🇬🇷Trikala, Karyes, Greece