Effects of Alpha Lipoic Acid Supplementation in G6PD Deficient Individuals After Acute Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Change in redox status after exercise
研究概览
简要总结
The purpose of this study is to investigate the effects of alpha-lipoic acid supplementation on redox status, physiological and biochemical parameters in G6PD deficient individuals after acute exercise.
详细描述
In a randomized double-blind, crossover design, 12 adult volunteers with G6PD deficiency of both sexes will be supplemented with either 600 mg of alpha-lipoic acid (experimental condition - EC) or placebo (control condition - CC) every day for 4 weeks. Before intervention, all participants will be informed about the study protocol, fill a medical history questionnaire and sign an informed consent form. Moreover, measurements of anthropometric characteristics and physiological parameters, as well as a VO2max test will be performed.
Participants will perform 4 trials of exercise (70% VO2max for 45min and 90% till exhaustion) before and after each condition. Blood samples will be collected before, immediately after and 1 hour after exercise. Moreover, measurements of anthropometric characteristics and physiological parameters will be performed before and after each condition. There will be a washout period of at 4 weeks between conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •G6PD deficiency
排除标准
- •Any uncontrolled health condition for which exercise is contraindicated
- •Current use of dietary supplements or drugs
- •Pregnant, pregnancy intention or breast feeding
研究组 & 干预措施
Alpha-lipoic acid
Alpha-lipoic acid supplementation (600 mg/day) for 4 weeks in a counterbalanced manner to 12 G6PD deficient individuals.
干预措施: Alpha-lipoic acid (Dietary Supplement)
Placebo
Placebo administration for 4 weeks in a counterbalanced manner to 12 G6PD deficient individuals.
干预措施: Placebo (Other)
结局指标
主要结局
Change in redox status after exercise
时间窗: Before, immediately after and 1 hour after each trial of exercise
Indices of blood redox status
次要结局
- Body composition(Before and after 4 weeks of alpha-lipoic acid supplementation, before and after 4 weeks of placebo)
- Blood pressure(Before and after 4 weeks of alpha-lipoic acid supplementation, before and after 4 weeks of placebo)
研究者
Athanasios Z. Jamurtas
Professor
University of Thessaly