The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory in Stroke, Parkinson, and Elderly Patients
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Change of Repeatable Battery for the Assessment of Neuropsychological Status
Study Overview
Brief Summary
The investigators hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.
Detailed Description
Excitatory (>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal gyrus.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 30 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Ischemic or hemorrhagic cerebrovascular lesion,
- •Parkinson's disease
Exclusion Criteria
- •With metal implantation
- •Dementia or severe cognitive impairment
Arms & Interventions
High frequency rTMS plus fNIRS
rTMS with neuroimage assessment of functional near infrared spectroscopy
Intervention: Functional near infrared spectroscopy (Device)
High frequency rTMS plus fNIRS
rTMS with neuroimage assessment of functional near infrared spectroscopy
Intervention: rTMS (Device)
Sham rTMS
Sham stimulation
Intervention: rTMS (Device)
High frequency rTMS
High frequency rTMS to modulate brain areas
Intervention: rTMS (Device)
Outcomes
Primary Outcomes
Change of Repeatable Battery for the Assessment of Neuropsychological Status
Time Frame: Up to 12 weeks
Test cognition including memory, attention, language...
Secondary Outcomes
- Change of Montreal Cognitive Assessment(Up to 12 weeks)
- Change of Fugl-Meyer Assessment , Wolf Motor Function Test(Up to 12 weeks)
Investigators
vghtpe user
Principal investigator
Taipei Veterans General Hospital, Taiwan