The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory

Not Applicable

• Conditions: Central Nervous System Diseases
• Interventions: Device: Functional near infrared spectroscopy; Device: rTMS

• Registration Number: NCT02006615
• Lead Sponsor: Taipei Veterans General Hospital, Taiwan

Brief Summary

The investigators hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.

Detailed Description

Excitatory (\>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal gyrus.

Study Timeline

• Study First Submitted: 2013-12-05
• Study First Submitted QC: 2013-12-05
• Study First Posted: 2013-12-10
• Study Start: 2017-06-02
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-06
• Last Update Posted: 2021-01-11
• Primary Completion: 2021-07-11
• Study Completion: 2021-07-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. Ischemic or hemorrhagic cerebrovascular lesion,
2. Parkinson's disease

Exclusion Criteria

• Seizure
• With metal implantation
• Dementia or severe cognitive impairment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High frequency rTMS plus fNIRS	rTMS	rTMS with neuroimage assessment of functional near infrared spectroscopy
High frequency rTMS	rTMS	High frequency rTMS to modulate brain areas
Sham rTMS	rTMS	Sham stimulation
High frequency rTMS plus fNIRS	Functional near infrared spectroscopy	rTMS with neuroimage assessment of functional near infrared spectroscopy

Primary Outcome Measures

Name	Time	Method
Change of Repeatable Battery for the Assessment of Neuropsychological Status	Up to 12 weeks	Test cognition including memory, attention, language...

Secondary Outcome Measures

Name	Time	Method
Change of Montreal Cognitive Assessment	Up to 12 weeks	Test cognition including memory, attention, and language.
Change of Fugl-Meyer Assessment , Wolf Motor Function Test	Up to 12 weeks	Test upper limb motor function.

Trial Locations

Locations (1)

Taipei Veterans General Hospital; 🇨🇳 Taipei, Taiwan