Coagulation Profile in Patients Undergoing Coronary Intervention Measured With Activated Clotting Time, Global Thrombosis Test and Platelet Inhibition VerifyNow P2Y12 Test
Overview
- Phase
- Not Applicable
- Sponsor
- Centre of Postgraduate Medical Education
- Enrollment
- 40
- Primary Endpoint
- ACT change
Overview
Brief Summary
The activated clotting time (ACT), global thrombosis test (GTT-3), platelet inhibition P2Y12 (VerifyNow) test and serum coagulation factors will be measured in patients undergoing coronary angiography (CA) and percutaneous coronary intervention (PCI).
Detailed Description
The activated clotting time (ACT), global thrombosis test (GTT-3) and platelet inhibition P2Y12 (VerifyNow) test and serum coagulation factors will be measured in patients undergoing coronary angiography (CA) and percutaneous coronary intervention (PCI) - 20 smoking and 20 non-smoking.The measurements will take place: before coronary angiography (CA), 10 minutes after unfractionated heparin (HNF), 2h after CA, 6h after CA, 30 days after CA
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients scheduled do CA \>18 years old
Exclusion Criteria
- •pregnancy
- •previous treatment with P2Y12 inhibitors, novel oral anticoagulants (NOAC) or warfarin acenocoumarol in last 24 hours
Outcomes
Primary Outcomes
ACT change
Time Frame: Baseline ACT , 10 minutes ACT, 2 hours ACT, 6 hours ACT, 30 days ACT
Activated Clotting Time
GTT-3 change
Time Frame: Baseline GTT-3, 10 minutes GTT-3, 2 hours GTT-3, 6 hours GTT-3, 30 days ACT
Global Thrombosis Test
VerifyNow change
Time Frame: Baseline VerifyNow, 10 minutes VerifyNow, 2 hours VerifyNow, 6 hours VerifyNow, 30 days ACT
Platelet inhibition P2Y12 test
Secondary Outcomes
No secondary outcomes reported