Analysis of Circulating Epithelial Tumor Cells in Peripheral Blood in Patients With Primary Non-metastatic Breast Cancer Under Adjuvant Radiotherapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 161
- 试验地点
- 1
- 主要终点
- Overall survival
研究概览
简要总结
The aim of this study was to investigate the systemic effect of radiotherapy on patients with primary non-metastatic breast cancer using CETC and to analyze possible changes in CETC quantity under adjuvant radiotherapy.
详细描述
In cooperation with the Women's Hospital of the Friedrich Schiller University in Jena, a total of 161 patients with clinically proven, primarily non-metastatic breast cancer were sampled and examined before and after radiotherapy over a period from 09/2002 to 09/2012. The MAINTRAC method was used to quantitatively determine the amount of CETC in the blood and to observe its peritherapeutic course.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •histologically confirmed invasive breast carcinoma
- •age >= 18 years
- •exclusive treatment at the Jena University Hospital
- •complete curative-intended adjuvant or definite radiotherapy
- •at least 2 blood collections (before the start of therapy, after the end of the RT)
排除标准
- •presence of metastases
- •recurrence
- •DCIS, inflammatory breast cancer
- •second malignancy <10 years before diagnosis of breast cancer
- •radiotherapeutic pretreatment
结局指标
主要结局
Overall survival
时间窗: up to 10 years
from the start of Radiotherapy until death / last seen during follow up
次要结局
- Disease free survival(up to 10 years)
研究者
Matthias Mäurer
Dr. Matthias Mäurer
University of Jena