The effects of eplerenone on left ventricular remodelling post-acute myocardial infarction: a double-blind placebo-controlled cardiac MR-based study.
Phase 1
- Conditions
- Post-myocardial infarction left ventricular dysfunction, in the absence of heart failure - clinical (i.e. Killip III or IV) or radiological - nor established diabetes mellitus.
- Registration Number
- EUCTR2004-004399-35-GB
- Lead Sponsor
- orth Glasgow Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
1. Age 18 or above
2. Acute myocardial infarction as defined by standard criteria
3. LVSD based on echocardiographic WMSI and LVEF < 40%
4. Ability to give written informed consent.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
1. Clinical or radiological heart failure
2. Established diabetes mellitus
3. Current use of K-sparing diuretics
4. Serum creatinine > 220mmol/l
5. Serum potassium > 5.0mmol/l
6. Pregnancy
7. Addison’s disease
8. MRI-incompatible (ferrous) sulphate prosthesis
9. Claustrophobia (unable to tolerate MR environment)
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method