Arterial wall inflammation measured with 18F-FDG PET/CT in patientswith statin intolerance before and after treatment with a PCSK-9 inhibitor
Completed
- Conditions
- Cardiovascular risk Statin intolerance
- Registration Number
- NL-OMON20315
- Lead Sponsor
- niversity of Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Increased CV-risk
Aged 50 years and older
Exclusion Criteria
Major exclusion criteria:
CV-event in last 3 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoint is the change in 18F-FDG target to background ratio (TBR) following 12 weeks of PCSK-9 inhibition
- Secondary Outcome Measures
Name Time Method The secondary endpoints are the difference in inflammatory parameters before and<br>after PCSK-9 inhibition and to evaluate whether there is a correlation between 18F-FDG PET<br>activity in arterial wall and circulating inflammatory markers