EUCTR2010-023976-16-BE进行中（未招募）不适用
Maternal antibodies against pertussis in neonates .
niversity of Antwerp0 个研究点开始时间: 2011年1月11日最近更新:
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Informed consent signed by the woman for her participation (vaccination and blood sample).
- •Informed consent signed by both parents for the inclusion of the children.
- •Pregnancy test negative in women at time of vaccination with Boostrix®.
- •Available cord samples from a previous study in which older siblings were participating.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •pertussis vaccination of the woman <10 years before study start
- •preterm delivery
- •severe diseases in mother or child
- •impaired immunology (diabetes mellitus, hiv, tumour…) in mother of child
- •use of immunoglobulins during pregnancy and use of blood products during last three months of pregnancy
- •use of immunoglobulins in children during the study period
- •previous booster vaccination with tetanus-diphtheria vaccine in less than two years before inclusion.
研究者
相似试验
已完成
4 期
*Premature infants and maternal pertussis immunization. Is second trimester vaccination beneficial?*whooping coughpertussisNL-OMON49737RIVM6,750
进行中（未招募）
1 期
‘Premature infants and maternal pertussis immunization. Is second trimester vaccination beneficial?women in their first trimester of pregnancyEUCTR2018-002976-41-NLRIVM120
进行中（未招募）
1 期
Immunization during pregnancy is an efficient and safe approach to provide protection against infectious pathogens affecting the young infant. The objective is to identify the determinants of antibody-mediated immunity in infants born to mothers immunized during pregnancy. A systems biology approaches will be used to delineate pre-vaccination and post-vaccination cellular and molecular correlates of the immune response to pertussis immunization in peripheral blood and in breastmilk.EUCTR2022-002697-80-BEniversité Libre de Bruxelles240
进行中（未招募）
1 期
TDaP (Tetanus, Diphtheria, acellular Pertussis) immunization during pregnancy results in an augmentation of maternal antibodies, which are in turn transferred from the mother to fetus and offer additional protection to the newborn infant during the first months of life. The role of these high maternal antibodies levels on the infant’s immune responses after vaccination will be assessed in term and preterm infants (the MAMA study).EUCTR2020-003466-39-BEniversity of Antwerp300
Unknown
不适用
Maternal Antibody in Milk After VaccinationVaccinationPregnancyBreastmilkPertussisNCT03982732St George's, University of London50