To compare the frequency of perioperative respiratory adverse events using sugammadex versus neostigmine following functional endoscopic sinus surgery

Introduction : Functional endoscopic sinus surgery (FESS) is a common procedure for managing sinus disorders, including chronic rhinosinusitis. Successful FESS not only relies on surgical technique but also on postoperative recovery, particularly neuromuscular function restoration and airway protection. Residual Neuromuscular Blockade (NMB) poses risks like airway obstruction and hypoxia, emphasizing the need for faster recovery. Sugammadex accelerates NMB reversal, reducing the risk of residual paralysis compared to neostigmine. This study aims to compare perioperative adverse events post-NMB reversal with sugammadex versus neostigmine in FESS patients. Aim: To compare the frequency of Perioperative respiratory adverse events (PRAE) using sugammadex or neostigmine as neuromuscular reversing agent following Functional Endoscopic Sinus Surgery (FESS). Objectives: To calculate and compare the frequency of Perioperative respiratory adverse events, Time to recovery of neuromuscular function and Hemodynamic Variation using sugammadex or neostigmine as a reversal agent after FESS surgery. Methodology : This randomized, controlled, prospective, double-blinded study will be conducted in 70 patients (aged 20-70 years) scheduled for Functional Endoscopic Sinus Surgery. The patients will be randomly allocated into two groups (35 patients each) to receive neuromuscular blockade reversal agent accordingly - Group A: Sugammadex 4 mg/kg intravenous; Group B: Neostigmine 0.05mg/kg + Glycopyrrolate 0.4mg intravenous. The frequency of Perioperative respiratory adverse events, time to recovery of neuromuscular function and hemodynamic variations will be noted and compared in the two groups. Significance of the study : This study seeks to enhance neuromuscular blockade reversal in Functional Endoscopic Sinus Surgery (FESS) by comparing Sugammadex and Neostigmine, crucial for patient safety and surgical success. Assessing their effectiveness, reversal speed, residual blockade incidence, and safety profile is vital for informed clinical decisions and better patient outcomes.