Critical Illness Among Recipients of Hematopoietic Cell Transplantation (CARE-HCT): a Prospective, Multicenter Observational Study in China
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 4,000
- 试验地点
- 6
- 主要终点
- Overall survival
研究概览
简要总结
This is a prospective, multicenter observational trial for patients who develop critical illness after hematopoietic cell transplantation. Patients who are admitted to the intensive care unit after undergoing hematopoietic cell transplantation at the participating medical centers will be enrolled in this study. The clinical characteristics, laboratory profiles, managements, and clinical outcomes will be prospectively collected.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who underwent hematopoietic cell transplantation at any of the participating medical centers.
- •Patients who are admitted to ICU for the management of critical illness following hematopoietic cell transplantation.
排除标准
- •Admitted to ICU for a reason other than critical illness (e.g., routine postoperative monitoring) and discharged within 2 days of ICU admission.
- •Unavailable in-ICU clinical outcomes or absent key baseline characteristics.
- •Any other conditions that, in the opinion of the investigator, can interfere with the interpretation of data.
研究组 & 干预措施
Critically ill patients after hematopoietic cell transplantation
Patients who are admitted to the intensive care unit after undergoing hematopoietic cell transplantation
结局指标
主要结局
Overall survival
时间窗: Before ICU discharge; within 6 months after ICU discharge; and within 1 year after ICU discharge.
Overall survival after admission to the intensive care unit.
次要结局
- Non-relapse mortality(Before ICU discharge; within 6 months after ICU discharge; and within 1 year after ICU discharge.)
- Relapse(At ICU admission and within 1 year of ICU discharge.)
- Long-term survival data(Up to 5 years after ICU discharge.)
- Transplant complication(At ICU admission and within 1 year of ICU discharge.)
- Organ failure(At ICU admission and within 1 year of ICU discharge.)
- Organ support therapy(At ICU admission and within 1 year after ICU discharge.)
研究者
Xiao Hui Zhang
MD
Peking University People's Hospital