The Analgesia of Pregabalin and Magnesium Sulphate in the postoperative period of Mastectomy with Axillary Lymphadenectomy
Not Applicable
- Conditions
- C04.588.180M01.975Womenbreast cancer
- Registration Number
- RBR-59m3sj
- Lead Sponsor
- Instituto do Câncer do Ceará
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
women over eighteen years of age; indicated the mastectomy with axillary lymphadenectomy; state physical classification of the American Society of Anesthesiologist (ASA) I and II; with the signed free informed consent form; no history of allergy to pregabalin or magnesium.
Exclusion Criteria
patients with previous history of liver or kidney disease or any other pathology that contraindicated the use of pregabalin or magnesium; who had used opioids 48 hours before surgery. patient who would perform breast reconstruction at the same surgical time. patients using calcium channel blockers
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method expected outcome 1: better analgesia in the magnesium + pregabalin sulfate group using the visual analogue scale to quantify the pain, using the mean + standard deviation, adopting a 95% confidence level when comparing the four groupss;endpoint found 1: decreased pain in the magnesium sulphate + pregabalin group, visual analogue scale of 1.45 ± 2.33; significantly better analgesia than the other groups with a variation lower than 0.001
- Secondary Outcome Measures
Name Time Method expected secondary outcome 1: longer extubation time in the groups using magnesium sulfate, calculated with the time of anesthesia, using mean ± standard deviation and variation less than 5% when compared to the other groups;secondary outcome found 1: there was no increase in the time of extubation in the groups that used magnesium sulphate when compared with the groups that did not use magnesium sulphate; calculated through the time of anesthesia; using the mean + standard deviation, 117.94 ± 26.44 minutes with a change of 0.613