CTRI/2018/04/013279
Active, not recruiting
Phase 4
A study to assess the efficacy of curcumin as an immunomodulator in Rheumatoid arthritis
Dr Padmanabha Shenoy D0 sites0 target enrollmentTBD
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Dr Padmanabha Shenoy D
- Status
- Active, not recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosed cases of rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria
- •On conventional DMARDs for at least last six months.
- •On sustained remission based on DAS 28 (DAS 28 \< 2\.6\) and SDAI ââ?°Â¤ 3\.3 and TJC (44\) \< 0 and SJC (44\) \< 0 for more than 6 months without requirement of corticosteroids or NSAIDs.
- •Documented remission status at a minimum of two consecutive visits during last 6 months .
Exclusion Criteria
- •Having other associated rheumatological diseases
- •Functional class IV
- •Abnormal liver function (defined as AST/ALT \> 3 X upper normal limit ) and active hepatits/cirrhosis
- •Abnormal renal function / chronic renal failure ( S. creatinine ââ?°Â¥ 2mg/dl)
- •Those who are currently on curcumin supplements
- •Known allergic reaction to curcumin
- •Major comorbidities like severe hypertension , uncontrolled diabetes mellitus , severe respiratory or cardiovascular disease , malignancy
- •Current or past use of biologics
- •Current use of Warfarin
- •Subjects with acute episodes of cholecystitis within last few months
Outcomes
Primary Outcomes
Not specified
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