Study Evaluating The Efficacy And Safety Of Bapineuzumab In Alzheimer Disease Patients
- Registration Number
- NCT00667810
- Lead Sponsor
- Pfizer
- Brief Summary
This is a study to evaluate the efficacy and safety of multiple doses of bapineuzumab in patients with mild to moderate Alzheimer Disease. Patients will receive either bapineuzumab or placebo. Each patient's participation will last approximately 1.5 years.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 901
- Diagnosis of probable Alzheimer Disease (AD), with Mini Mental State Examination (MMSE) score of 16-26, and brain magnetic resonance imaging (MRI) consistent with the diagnosis of AD
- Concurrent use of cholinesterase inhibitor or memantine allowed, if stable
- Caregiver will participate and be able to attend clinic visits with patient
- Significant neurological disease other than AD
- Major psychiatric disorder
- Contraindication to undergo brain MRI [e.g., pacemaker, cerebrospinal fluid (CSF) shunt, or foreign metal objects in the body]
- Women of childbearing potential
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Bapineuzumab 0.5 mg/kg bapineuzumab - Bapineuzumab 1.0 mg/kg bapineuzumab - Placebo placebo -
- Primary Outcome Measures
Name Time Method The Change From Baseline in the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog)/11 Total Score at Week 78 78 weeks The ADAS-Cog is a multi-item, objective measure of cognitive function. The scale evaluates memory, language, and praxis with items such as orientation, word recall, word recognition, object identification, comprehension, and the completion of simple tasks. Analysis of the ADAS-Cog for this study was based upon an 11 item score from the following items 1) word recall task, 2) naming objects and fingers, 3) following commands, 4) constructional praxis, 5) ideational praxis, 6) orientation, 7) word recognition, 8) remembering test instructions, 9) spoken language ability, 10) word finding difficulty in spontaneous speech, and 11) comprehension. This scale had to be administered by a trained and certified psychometric rater who did not have access to any information regarding adverse events experienced. The ADAS-Cog/11 ranged from 0 to 70 points, with higher scores indicating a greater degree of impairment. A negative change from baseline indicates a decrease in cognitive impairment.
The Change From Baseline in the Disability Assessment for Demential (DAD) Total Score at Week 78 78 weeks The DAD measures instrumental and basic activities of daily living in participants with Alzheimer's Disease (AD). The DAD is administered to the participants'caregiver in the form of an interview. This scale had to be administered by a trained and certified global rater who did not have access to any information regarding adverse events experienced by the participant. This scale assesses a participants' ability to initiate, plan, and perform activities related to hygiene, dressing, continence, eating, meal preparation, telephoning, going on an outing, finance and correspondence, medications, leisure, and housework. Each item can be scored as 1 = yes, 0 = no, non applicable = NA. A total score is obtained by adding the rating for each question and converting this total score out of 100. Higher scores indicate better function; a positive change from baseline indicates an improvement.
- Secondary Outcome Measures
Name Time Method Time to First Clinically Meaningful Deterioration on ADAS-Cog/11 Total Score (United States [US] Analysis Plan) 78 weeks The time to first clinically meaningful deterioration (for the US) was defined as the first time a participant experienced an increase (worsening) from baseline in ADAS-Cog/11 total score of \>=7.
Change From Baseline in Clinical Dementia Rating Sum of Boxes (CDR-SOB) Total Score at Week 78 78 Weeks The CDR-SOB is a global clinical staging instrument that sums 6 clinical ratings: 1) memory, 2) orientation, 3) judgment and problem solving, 4) involvement in community affairs, 5) home and hobbies, and 6) personal care based on the Clinical Dementia Rating Scale (CDR) interview. The CDR includes discussions with the participant and caregiver using a structured format. This scale had to be administered by a trained and certified global rater who did not have access to any information regarding adverse events experienced by the participant. CDR-SOB total score range is 0 (least impairment) to 18 (most impairment); a negative change from baseline indicates an improvement.
The Change From Baseline in Phospho-tau Levels in the Cerebrospinal Fluid (CSF) at Week 71. 71 Weeks Biomarkers CSF phospho-tau (p-tau) is an indicator of neuronal injury and neurodegeneration. An elevation in levels of tau, as well as specific p-tau species, is thought to be a marker for progressive cellular degeneration in AD. Accordingly, a reduction from baseline in levels of CSF tau in participants who received bapineuzumab compared with participants who received placebo may be indicative of a reduction in neuronal loss in participants treated with bapineuzumab.
Divergence of Effect on the ADAS-Cog/11 Total Scores From Week 39 to Week 78 39 Weeks The MMRM estimated slope (based on linear contrasts) of the differences between bapineuzumab and placebo for the ADAS-Cog/11 total scores from Week 39 to Week 78 was presented.
Time to First Clinically Meaningful Deterioration on DAD Total Score (US Analysis Plan) 78 Weeks The time to first clinically meaningful deterioration was defined as the first time a participant experienced a decrease (worsening)from baseline in DAD total score of \>=12.
Percentage of Participants With Worsening From Baseline in DAD Total Score at Week 78 (US Analysis Plan) 78 weeks Percentage of participants whose decrease (worsening) from baseline to Week 78 in DAD total score was \<12.
Change From Baseline in Dependence Scale Total Score at Week 78 78 Weeks The Dependence Scale (DS) is a 13-item, caregiver-rated instrument for determining the amount of support required by a participant with AD. The DS total score ranges from 0 to 15, with higher scores indicating more need for assistance. The DS was administered as an interview to the caregiver at scheduled study visits.
Time to Median Placebo Deterioration on DAD Total Score 78 Weeks The time to first median placebo deterioration (for the EU) was defined as the first time a participant experienced a decrease (worsening) in DAD total score greater than or equal to the median worsening at Week 78 in the placebo group.
Percentage of Participants With Worsening From Baseline in ADAS-Cog/11 Total Score at Week 78 (US Analysis Plan) 78 Weeks Percentage of participants whose increase (worsening) from baseline to Week 78 in ADAS-Cog/11 total score is \<7.
Percentage of Participants With Worsening From Baseline in DAD Total Score at Week 78 (European Union Analysis Plan) 78 Weeks Percentage of participants whose decrease (worsening) from baseline to Week 78 in DAD total score was at most 0, 6, 12 points.
The Change From Baseline in Brain Amyloid Burden at Week 71. 71 Weeks Brain amyloid burden as imaged by 11C-Pittsburgh compound B (PiB) positron emission tomography (PET). The latter is a semiquantitative measure of the extent of fibrillar amyloid in the brain. PIB PET measurements were made in cortical regions found to have the highest burden of fibrillar amyloid at autopsy in participants diagnosed as having Alzheimer's pathology, and also regions reported to have the highest average retention of PIB signal in previous PET studies enrolling participants with probable AD. This parameter reflects overall brain amyloid deposition as indexed by imaging. The change from baseline was measured as average standard uptake value ratio (SUVr) in prespecified regions of interest (ROI) assessed by PIB PET imaging in a subset of participants.
The Change From Baseline in Brain Volume at Week 71 71 Weeks Brain volume was examined in a subset of participants by Magnetic Resonance Imaging Brain Boundary Shift Integral (MRI BBSI). Cerebral atrophy correlates closely with the gradual cognitive decline in AD and can be visualized by MRI. The BBSI technique involves positional matching of serial 3-dimensional MRI brain images, such that brain MRI-image volumes were first registered and then subtracted from each other. Atrophy rates would generally be expected to be lower if the underlying disease was attenuated by effective treatment.
Divergence of Effect on the DAD Total Scores From Week 39 to Week 78 39 weeks The MMRM estimated slope (based on linear contrasts)of the differences between bapineuzumab and placebo for the DAD total scores from Week 39 to Week 78 was presented.
Time to Median Placebo Deterioration on ADAS-Cog/11 Total Score (European Union [EU] Analysis Plan) 78 Weeks The time to first median placebo deterioration (for the EU) was defined as the first time a subject experienced an increase from baseline (worsening) in ADAS Cog/11 total score greater than or equal to the median worsening observed at Week 78 in the placebo group. The Kaplan Meier estimate of the median time to first median placebo deterioration in ADAS Cog/11 total score was presented.
Percentage of Participants With Worsening From Baseline in ADAS-Cog/11 Total Score at Week 78 (European Union Analysis Plan) 78 Weeks Percentage of participants whose increase (worsening) in ADAS-Cog/11 total score from baseline to Week 78 was at most 0, 3, 7 points.
Trial Locations
- Locations (331)
Clinical Trials, Inc.
🇺🇸Little Rock, Arkansas, United States
Center for Healthy Aging
🇺🇸Greenwich, Connecticut, United States
Chase Medical Research, LLC
🇺🇸Waterbury, Connecticut, United States
Marty's Pharmacy
🇺🇸Flowood, Mississippi, United States
Bendheim Cancer Center
🇺🇸Greenwich, Connecticut, United States
Research Center for Clinical Studies, Inc.
🇺🇸Norwalk, Connecticut, United States
Memory Enhancement Center of America, Inc.
🇺🇸Eatontown, New Jersey, United States
James Gary Booker, MD, APMC
🇺🇸Shreveport, Louisiana, United States
Lake Charles Clinical Trials
🇺🇸Lake Charles, Louisiana, United States
Spectrum Home Solutions
🇺🇸Great Falls, Montana, United States
CBH Health, LLC
🇺🇸Rockville, Maryland, United States
Memory Enhancement Center of New Jersey, Inc.
🇺🇸Toms River, New Jersey, United States
Psicomedica Research Group
🇨🇱Santiago, Chile
Especialidades Medicas L&S
🇨🇱Santiago, Chile
Cliniques Universitaires Saint-Luc
🇧🇪Bruxelles, Belgium
Ita-Suomen Yliopisto
🇫🇮Kuopio, Finland
Yachiyo Hospital
🇯🇵Aichi, Japan
Shinozuka Hospital
🇯🇵Gunma, Japan
National Hospital Organization Hiroshima-nishi Medical Ctr.
🇯🇵Hiroshima, Japan
Nippon Medical School Musashikosugi Hospital
🇯🇵Kanagawa, Japan
Centre de Recherche ADAPRA Inc.
🇨🇦L'Ancienne-Lorette, Quebec, Canada
Recherche Clinique de Neurologie
🇨🇦Montreal, Quebec, Canada
Nagoya City University Hospital
🇯🇵Nagoya, Aichi,, Japan
National Hospital Organization Chiba-East Hospital
🇯🇵Chiba, Japan
Nippon Medical School Chiba Hokusoh Hospital
🇯🇵Chiba, Japan
Nishi-Kobe Medical Center
🇯🇵Hyogo, Japan
Kobe City Hospital Org Kobe City Medical Cente West Hp
🇯🇵Hyogo, Japan
Diex Research Sherbrooke Inc.
🇨🇦Sherbrooke, Quebec, Canada
Gunma University Hospital
🇯🇵Gunma, Japan
Iwate Medical University Hospital
🇯🇵Iwate, Japan
University Hospital Center Zagreb
ðŸ‡ðŸ‡·Zagreb, Croatia
Szpital Uniwersytecki w Krakowie,Oddzial Kliniczny Klinik Chorób Wewnetrznych
🇵🇱Krakow, Poland
Turku University Hospital
🇫🇮Turku, Finland
Maebashi Red Cross Hospital
🇯🇵Gunma, Japan
National Hospital Organization Niigata National Hospital
🇯🇵Niigata, Japan
Juntendo Tokyo Koto Geriatric Medical Center
🇯🇵Tokyo, Japan
Amphia Ziekenhuis
🇳🇱Breda, Netherlands
National Hospital Organization Minami-Okayama Medical Center
🇯🇵Okayama, Japan
Shonan Atsugi Hospital
🇯🇵Kanagawa, Japan
Rakuwakai Otowa Hospital
🇯🇵Kyoto, Japan
National HP.Org.Shizuoka Inst.Epilepsy,Neurological Disorder
🇯🇵Shizuoka, Japan
National Hospital Organization Minami-Kyoto Hospital
🇯🇵Kyoto, Japan
National Hospital Organization Maizuru Medical Center
🇯🇵Kyoto, Japan
National Hospital Organization Matsumoto Medical Center
🇯🇵Nagano, Japan
Osaka City University Hospital
🇯🇵Osaka, Japan
Tokyo Medical University Hospital
🇯🇵Tokyo, Japan
Tokyo Medical University Hachioji Medical Center
🇯🇵Tokyo, Japan
Kansai Medical University Takii Hospital
🇯🇵Osaka, Japan
Juntendo University Hospital
🇯🇵Tokyo, Japan
Jeroen Bosch Ziekenhuis
🇳🇱s. Hertogenbosch, Netherlands
Oddzial Neurologiczny i Udarowy Szpital Wolski im. dr Anny Gostynskiej,
🇵🇱Warszawa, Poland
Saint-Petersburg Psychoneurological Research Institute n.a. V.M.Bekhterev
🇷🇺Saint-Petersburg, Russian Federation
1. Neurologicka klinika
🇸🇰Bratislava, Slovakia
Univerzitna nemocnica Bratislava
🇸🇰Bratislava, Slovakia
OCA Hospital
🇲🇽Monterrey, Nuevo León, Mexico
National Hospital Organization Tokyo National Hospital
🇯🇵Tokyo, Japan
Vrije Universiteit Medisch Centrum
🇳🇱Amsterdam, Netherlands
Catharina Ziekenhuis
🇳🇱Eindhoven, Netherlands
NZOZ "SYNAPSA", ul. Niska 5/1
🇵🇱Kielce, Poland
Instituto Biomedico de Investigacion A.C
🇲🇽Aguascalientes, Mexico
Medisch Centrum Leeuwarden
🇳🇱Leeuwarden, Netherlands
NZOZ "NEURO-KARD" "ILKOWSKI I PARTNERZY" Spolka Partnerska Lekarzy
🇵🇱Poznan, Poland
Hospital Fernando da Fonseca
🇵🇹Amadora, Portugal
Clinical Centre Kragujevac
🇷🇸Kragujevac, Serbia
Neurologicka klinika
🇸🇰Martin, Slovakia
Neurologicke oddelenie FNsP Zilina
🇸🇰Zilina, Slovakia
Hospital General Universitario de Elche
🇪🇸Elche, Alicante, Spain
Samodzielny Publiczny Centralny Szpital Kliniczny, Katedra i Klinika
🇵🇱Warszawa, Poland
Hospitais Da Universidade De Coimbra
🇵🇹Coimbra, Portugal
Hospital Santa Maria
🇵🇹Lisboa, Portugal
Psychiatricka nemocnica Michalovce, n.o.
🇸🇰Michalovce, Slovakia
Hospital Universitario Son Espases
🇪🇸Palma de Mallorca, Islas Baleares, Spain
Klinicki centar Vojvodine
🇷🇸Novi Sad, Vojvodina, Serbia
Interregional clinicodiagnostic center
🇷🇺Kazan, Russian Federation
Chair of nervous system diseases
🇷🇺Saint-Petersburg, Russian Federation
Klinicki centar Srbije
🇷🇸Beograd, Serbia
Psychiatricka ambulancia
🇸🇰Bratislava, Slovakia
Vseobecna nemocnica Rimavska Sobota
🇸🇰Rimavska Sobota, Slovakia
CHUV Lausanne
🇨ðŸ‡Lausanne, VD, Switzerland
Hospital Mutua de Terrasa
🇪🇸Terrassa, Barcelona, Spain
CLONUS
🇪🇸Palma de Mallorca, Islas Baleares, Spain
Signet Research
🇳🇿Christchurch, New Zealand
NZOZ Dom Suer Ryder, Pallmed Sp. z o.o.
🇵🇱Bydgoszcz, Poland
Kennemer Gasthuis
🇳🇱Haarlem, Netherlands
Saint Petersburg Psychoneurological Research Institute n.a. V.M.Bekhterev
🇷🇺Saint-Petersburg, Russian Federation
Boston University
🇺🇸Boston, Massachusetts, United States
The Ohio State University
🇺🇸Columbus, Ohio, United States
Clinical Trials Research Services, LLC
🇺🇸Pittsburgh, Pennsylvania, United States
Loma Linda University Medical Center
🇺🇸Loma Linda, California, United States
Pharmacology Research Institute
🇺🇸Newport Beach, California, United States
Margolin Brain Institute
🇺🇸Fresno, California, United States
Associated Neurologists of Southern Connecticut, P.C.
🇺🇸Fairfield, Connecticut, United States
Neurologic Consultants, P.A.
🇺🇸Fort Lauderdale, Florida, United States
Alpine Clinical Research Center, Inc.
🇺🇸Boulder, Colorado, United States
ATP Clinical Research, Incorporated
🇺🇸Costa Mesa, California, United States
Senior Clinical Trials, Incorporated
🇺🇸Laguna Hills, California, United States
Medical Research and Health Education Foundation, Incorporated
🇺🇸Columbus, Georgia, United States
Drug Shipment/ Storage
🇺🇸Wichitia, Kansas, United States
Bringham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
IDS Pharmacy
🇺🇸Boston, Massachusetts, United States
Advanced Imaging
🇺🇸Ocala, Florida, United States
Neurostudies.net
🇺🇸Lawrenceville, Georgia, United States
Alexian Brothers Neurosciences Institute
🇺🇸Elk Grove Village, Illinois, United States
Collaborative Neuroscience Network, Inc.
🇺🇸Long Beach, California, United States
Infusion Care Pharmacey
🇺🇸Laguna Hills, California, United States
Neurostudies Inc
🇺🇸Port Charlotte, Florida, United States
NeuroTrials Research, Incorporated
🇺🇸Atlanta, Georgia, United States
Dedicated Clinical Research
🇺🇸Goodyear, Arizona, United States
MD Clinical
🇺🇸Hallandale Beach, Florida, United States
Renstar Medical Research
🇺🇸Ocala, Florida, United States
University of Rochester/Strong Memorial Hospital
🇺🇸Rochester, New York, United States
Bradenton Research Center, Incorporated
🇺🇸Bradenton, Florida, United States
Hospital of the University of Pennslyvania
🇺🇸Philadelphia, Pennsylvania, United States
UPENN Clinical and Translational Research Center (CTRC)
🇺🇸Philadelphia, Pennsylvania, United States
Red River Medical Recearch Center, LLC
🇺🇸Oklahoma City, Oklahoma, United States
Methodist Center for Senior Health
🇺🇸Peoria, Illinois, United States
Alexian Brothers Medical Center
🇺🇸Elk Grove Village, Illinois, United States
South Bay Internal Medicine
🇺🇸Sun City, Florida, United States
Advanced Neurology Specialists
🇺🇸Great Falls, Montana, United States
Penn Memory Center
🇺🇸Philadelphia, Pennsylvania, United States
Methodist Medical Center of Illinois
🇺🇸Peoria, Illinois, United States
Palm Beach Neurological Center
🇺🇸Palm Beach Gardens, Florida, United States
Columbus Diagnostic Center (MRI)
🇺🇸Columbus, Georgia, United States
NeuroStudies.net
🇺🇸Decatur, Georgia, United States
Radio Pharmacy
🇺🇸Paducah, Kentucky, United States
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States
Neurocare, Incorporated
🇺🇸Newton, Massachusetts, United States
AD-CARE, University of Rochester Medical Center
🇺🇸Rochester, New York, United States
Methodist Diagnostic Center
🇺🇸Peoria, Illinois, United States
Northeast Radiology
🇺🇸Brewster, New York, United States
Neurological Care of Central New York
🇺🇸Liverpool, New York, United States
Investigational New Drug Services, IDS Pharmacy
🇺🇸Philadelphia, Pennsylvania, United States
Cemic University Hospital
🇦🇷Buenos Aires, Argentina
Alzheimer's Memory Center
🇺🇸Charlotte, North Carolina, United States
Carolina Neuropsychological Services, Inc.
🇺🇸Raleigh, North Carolina, United States
Precise Research Centers
🇺🇸Flowood, Mississippi, United States
Rhode Island Mood and Memory Research Institute
🇺🇸East Providence, Rhode Island, United States
Butler Hospital
🇺🇸Providence, Rhode Island, United States
Sunnybrook Health Sciences Centre
🇨🇦Toronto, Ontario, Canada
The Ohio State University Hospitals Clinic
🇺🇸Columbus, Ohio, United States
Neurology Clinic, PC
🇺🇸Cordova, Tennessee, United States
The Compounding Pharmacy
🇺🇸Hickory, North Carolina, United States
Abington Neurological Associates
🇺🇸Willow Grove, Pennsylvania, United States
Royal Adelaide Hospital
🇦🇺Adelaide SA, Australia
The Memory Clinic
🇳🇿Auckland, NZ, New Zealand
ALPHA Recherche Clinique
🇨🇦Quebec, Canada
Hornsby Kuringai Hospital
🇦🇺Hornsby, New South Wales, Australia
Heidelberg Repatriation Hospital/ Medical and Cognitive Research Unit
🇦🇺West Heidelberg, Victoria, Australia
Sestre milosrdnice Zagreb
ðŸ‡ðŸ‡·Zagreb, Croatia
Unita' Operativa Complessa di Neurologia
🇮🇹Catania, Italy
Ospedale S. Raffaele
🇮🇹Milano, Italy
Fondazione IRCCS- Istituto Neurologico Carlo Besta
🇮🇹Milano, Italy
CHU Hopital Nord
🇫🇷Amiens, France
Hôpital Roger Salengro
🇫🇷Lille, France
Hopital Maisonneuve-Rosemont
🇨🇦Montreal, Quebec, Canada
University of Virginia General Clinical Research Center
🇺🇸Charlottesville, Virginia, United States
CHU de Dijon
🇫🇷Dijon, France
Universita Politecnica delle Marche
🇮🇹Ancona, Italy
Hopital Sainte Marguerite
🇫🇷Marseille, France
Universita degli Studi di Firenze
🇮🇹Firenze, Italy
CHU de Caen
🇫🇷Caen, France
CHU Nord - Hôpital Guillaume et René Laënnec
🇫🇷Nantes - Saint Herblain, France
Toronto Memory Program
🇨🇦Toronto, Ontario, Canada
University of Viriginia Investigational Pharmacy
🇺🇸Charlottesville, Virginia, United States
Az. St. Jan Ruddershove 35
🇧🇪Brugge, Belgium
CHU Hôpital Gui de Chaulliac
🇫🇷Montpellier, France
Groupe Hospitalier Pitie-Salpetriere
🇫🇷Paris Cedex 13, France
CHU La Milétrie
🇫🇷Poitiers, France
C.H.U de Reims
🇫🇷Reims, France
CHU - Hopital Charles Nicolle
🇫🇷Rouen, France
CeSI (Centro di Scienze dell'invecchiamento) -
🇮🇹Chieti, Italy
Gosford Hospital
🇦🇺Gosford, New South Wales, Australia
Klinik fur Psychiatrie und Psychotherapie
🇩🇪Berlin, Germany
Ospedale S. Gerardo
🇮🇹Monza, Italy
CHRU Hôtel Dieu
🇫🇷Rennes, Cedex, France
CHU Purpan - Hôpital Casselardit
🇫🇷Toulouse, France
Universitaet Regensburg
🇩🇪Regensburg, Germany
Clinica Neurologica
🇮🇹Roma, Italy
Azienda Ospedaliera Spedali Civili di Brescia
🇮🇹Brescia, Italy
Azienda Ospedaliera S. Gerardo di Monza Università di Milano Bicocca
🇮🇹Monza, Italy
Groupe Hospitalier Broca-La Rochefoucauld
🇫🇷Paris, France
Hôpital Purpan
🇫🇷Toulouse, France
Universita degli Studi di Siena
🇮🇹Siena, Italy
Hôpital la Timone
🇫🇷Marseille, France
Ortenau Klinikum
🇩🇪Offenburg, Germany
Tokyo Metoropolitan Health and Med. Treatment Co. Ebara Hosp
🇯🇵Ota-ku, Tokyo, Japan
Kashiwado Hospital
🇯🇵Chiba, Japan
KonKuk University Hospital, Department of NeuroPsychiatry
🇰🇷Seoul, Korea, Republic of
Unita' Operativa C - Riabilitazione Neurologica
🇮🇹Roma, Italy
National Hospital Organization Kokura Medical Center
🇯🇵Fukuoka, Japan
ClÃnica CIMA
🇪🇸Barcelona, Spain
Seoul National University Bundang Hospital, Department of Psychiatry
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
St Augustine's Medical Centre 2
🇿🇦Durban, Kwa Zulu Natal, South Africa
Kagawa University Hospital
🇯🇵Kagawa, Japan
Yokohama City University Medical Center
🇯🇵Kanagawa, Japan
Okayama University Hospital
🇯🇵Okayama, Japan
Denmar Clinic
🇿🇦Pretoria, Gauteng, South Africa
Hospital de la Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Boithuso Caregivers
🇿🇦Johannesburg, Gauteng, South Africa
Skanes Universitetssjukhus, Neuropsykiatriska
🇸🇪Malmo, Sweden
Kings College Hospital
🇬🇧London, United Kingdom
Hospital de Cruces
🇪🇸Baracaldo, Spain
Hopitaux Universitaires de Geneve
🇨ðŸ‡Thonex-Geneva, Switzerland
The clinic: Minnes- och geriatrikmottagningen
🇸🇪Uppsala, Sweden
Llandough Hospital
🇬🇧Penarth, United Kingdom
Hospital Virgen del Puerto
🇪🇸Plasencia, Caceres, Spain
Fundació ACE Institut Catala de Neurociences Aplicades
🇪🇸Barcelona, Spain
Royal Hallamshire Hospital
🇬🇧Sheffield, United Kingdom
Northampton General Hospital NHS Trust
🇬🇧Northampton, United Kingdom
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
PET center
🇸🇪Uppsala, Sweden
Grenoside Grange Hospital
🇬🇧Sheffield, United Kingdom
Hospital Universitario La Princesa
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
MRI Dept: ORKI
🇸🇪Uppsala, Sweden
MAC UK Neuroscience, Ltd.
🇬🇧Bradford, West Yorkshire, United Kingdom
Glasgow Memory Clinic
🇬🇧Glasgow, United Kingdom
KU - Wichita
🇺🇸Wichita, Kansas, United States
Hollywood Private Hospital
🇦🇺Nedlands, Western Australia, Australia
Abington Memorial Hospital
🇺🇸Abington, Pennsylvania, United States
Banner Alzheimer's Institute
🇺🇸Phoenix, Arizona, United States
Jeffrey S. Gitt, DO, PC
🇺🇸Phoenix, Arizona, United States
The Compounding Center (IP Mixing Only)
🇺🇸Phoenix, Arizona, United States
Hope Research Institute
🇺🇸Phoenix, Arizona, United States
Coordinated Clinical Research
🇺🇸San Diego, California, United States
Sharp Infusion Therapy Center
🇺🇸San Diego, California, United States
LabCorp
🇺🇸San Diego, California, United States
Sharp Mesa Vista Hospital
🇺🇸San Diego, California, United States
San Francisco Clinical Research Center
🇺🇸San Francisco, California, United States
Innovative Clinical Trials
🇺🇸San Antonio, Texas, United States
Integra Clinical Research, LLC
🇺🇸San Antonio, Texas, United States
Vista Infusions
🇺🇸San Antonio, Texas, United States
Inventive Infusion Solutions
🇺🇸San Antonio, Texas, United States
University of Alabama-Birmingham
🇺🇸Birmingham, Alabama, United States
Professional Corporation of Psychiatry
🇺🇸Oklahoma City, Oklahoma, United States
Flourish Integrative Pharmacy
🇺🇸Oklahoma City, Oklahoma, United States
The Mile High Research Center
🇺🇸Denver, Colorado, United States
Providence Brain Institute
🇺🇸Portland, Oregon, United States
Kingshill Research Centre
🇬🇧Swindon, United Kingdom
Hospital del Mar
🇪🇸Barcelona, Spain
Ohio State University Imaging at Martha Morehouse
🇺🇸Columbus, Ohio, United States
Psychology Associates
🇺🇸Mishawaka, Indiana, United States
Simpson's Pharmacy
🇺🇸Pawtucket, Rhode Island, United States
Bruyere Continuing Care
🇨🇦Ottawa, Ontario, Canada
Michigan State University
🇺🇸Lansing, Michigan, United States
Hôpital Neurologique
🇫🇷Bron, France
Hôpitaux Civils de Colmar
🇫🇷Colmar, France
Hôpital Cimiez
🇫🇷Nice, France
Faculty Physicians and Surgeons of Loma Linda University School of Medicine
🇺🇸Loma Linda, California, United States
Sharp and Children's MRI Center, LLC
🇺🇸San Diego, California, United States
Sharp Memorial Hospital
🇺🇸San Diego, California, United States
Associated Neurologists, PC
🇺🇸Danbury, Connecticut, United States
JEM Research Institute LLC
🇺🇸Atlantis, Florida, United States
Premiere Research Institute
🇺🇸West Palm Beach, Florida, United States
Dekalb Neurology Associates, LLC/NeuroStudies.net, LLC
🇺🇸Decatur, Georgia, United States
Methodist Medical Center Research Department
🇺🇸Peoria, Illinois, United States
Memorial Medical Center
🇺🇸Springfield, Illinois, United States
Elkhart Clinic, LLC
🇺🇸Elkhart, Indiana, United States
Four Rivers Clinical Research, Incorporated
🇺🇸Paducah, Kentucky, United States
ActivMed Practices and Research, Inc.
🇺🇸Haverhill, Massachusetts, United States
Springfield Neurology Associates, LLC
🇺🇸Springfield, Massachusetts, United States
Comprehensive Clinical Research
🇺🇸Berlin, New Jersey, United States
Hattiesburg Clinic
🇺🇸Hattiesburg, Mississippi, United States
Alzheimer's Research Corporation
🇺🇸Manchester, New Jersey, United States
Clinical Study Center of Asheville, LLC
🇺🇸Asheville, North Carolina, United States
Raleigh Neurology Associates, PA
🇺🇸Raleigh, North Carolina, United States
The Ohio State University Medical Center
🇺🇸Columbus, Ohio, United States
Clinical Trial Center, LLC
🇺🇸Jenkintown, Pennsylvania, United States
Hospital of the University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Radiant Research, Incorporated
🇺🇸Greer, South Carolina, United States
Medical University of South Carolina
🇺🇸North Charleston, South Carolina, United States
Texas Neurology, P.A.
🇺🇸Dallas, Texas, United States
Southwestern Vermont Healthcare
🇺🇸Bennington, Vermont, United States
CDAMS Ballarat Base Hospital
🇦🇺Ballarat, Victoria, Australia
Hospital Italiano de Buenos Aires
🇦🇷Buenos Aires, Argentina
The Queen Elizabeth Hospital
🇦🇺Woodville South, South Australia, Australia
ZNA Middelheim / Neurologie
🇧🇪Antwerpen, Belgium
McCusker Alzheimer's Research Foundation Inc.
🇦🇺Nedlands, Western Australia, Australia
Universitair Ziekenhuis Antwerpen
🇧🇪Edegem, Belgium
University Hospital Gathuisberg
🇧🇪Leuven, Belgium
H.-Hartziekenhuis Roeselare-Menen
🇧🇪Roeselare, Belgium
Medical Specialists of the Palm Beaches
🇺🇸Atlantis, Florida, United States
North Broward Medical Center
🇺🇸Deerfield Beach, Florida, United States
Southern Illinois University School of Medicine
🇺🇸Springfield, Illinois, United States
Neurology & Neuroscience Center of Ohio
🇺🇸Toledo, Ohio, United States
Brain Matters Research
🇺🇸Delray Beach, Florida, United States
General Clinical Research Center
🇺🇸Boston, Massachusetts, United States
Clinical Trials of America, Incorporated
🇺🇸Hickory, North Carolina, United States
Roskamp Institute
🇺🇸Sarasota, Florida, United States
Healthsouth Blue Ridge Surgery Center
🇺🇸Raleigh, North Carolina, United States
Wake Radiology Associates
🇺🇸Raleigh, North Carolina, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Pacific Medical Centers
🇺🇸Seattle, Washington, United States
University of North Texas Health Science Center
🇺🇸Fort Worth, Texas, United States
Grayline Clinical Drug Trials
🇺🇸Wichita Falls, Texas, United States
University of Virginia Neurology
🇺🇸Charlottesville, Virginia, United States
Hospital Universitario La Paz
🇪🇸Madrid, Spain
St. Josef-Klinikum
🇩🇪Bochum, Germany
Hospital Universitario Virgen de la Arrixaca
🇪🇸Murcia, Spain
Hospital of the University of Pennsylvania (PET)
🇺🇸Philadelphia, Pennsylvania, United States
Kobe University Hospital
🇯🇵Hyogo, Japan
Osaka University Hospital
🇯🇵Osaka, Japan
Nizhny Novgorod regional clinical hospital n.a. N.A.Semashko
🇷🇺Nizhny Novgorod, Russian Federation
Saint-Petersburg State institution of healthcare, City geriatric medico-social center
🇷🇺Saint-Petersburg, Russian Federation
The Osteoporosis and Memory Centre
🇿🇦Johannesburg, Gauteng, South Africa
Panorama Psychiatry and Memory Clinic
🇿🇦Panorama, Western Cape, South Africa
Hospital Divino Valles
🇪🇸Burgos, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Memory Clinic Neuro-Psychologie Zentrum
🇨ðŸ‡Basel, BS, Switzerland
Newcastle General Hospital
🇬🇧Newcastle upon Tyne, United Kingdom
Clinical Investigation and Research Unit (CIRU)
🇬🇧Brighton, United Kingdom
MAC UK Neuroscience Ltd
🇬🇧Blackpool, Lancashire, United Kingdom
Dept. of Neurosciences Charing Cross Hospital
🇬🇧London, United Kingdom
Compass Research, LLC
🇺🇸Orlando, Florida, United States
Foers Medical Arts Pharmacy
🇺🇸Bethesda, Maryland, United States
Institute for Neurodegenerative Disorders
🇺🇸New Haven, Connecticut, United States
Yale University School of Medicine
🇺🇸New Haven, Connecticut, United States
Institutional Review Board / Ethics Committee
🇺🇸New Haven, Connecticut, United States
Yale PET Center
🇺🇸New Haven, Connecticut, United States
Stedman Clinical Trials, LLC
🇺🇸Tampa, Florida, United States
University of Michigan Health System
🇺🇸Ann Arbor, Michigan, United States
University of Michigan Hospital
🇺🇸Ann Arbor, Michigan, United States
Yale-New Haven Hospital
🇺🇸New Haven, Connecticut, United States
Norman S. Werdiger, MD
🇺🇸New Haven, Connecticut, United States
The Center for Pharmaceutical Research
🇺🇸Kansas City, Missouri, United States
Medical University of South Carolina Hospitals and Clinics
🇺🇸Charleston, South Carolina, United States
Medical University of South Carolina Investigational Drug Service
🇺🇸Charleston, South Carolina, United States
Louisiana Research Associates Inc
🇺🇸New Orleans, Louisiana, United States
Austin Infusion Centers
🇺🇸Austin, Texas, United States
Senior Adults Specialty Research
🇺🇸Austin, Texas, United States
Centre for Memory and Aging
🇨🇦North York, Ontario, Canada