Creatine Supplementation in Young Healthy Adults

Not Applicable

Recruiting

• Conditions: Improve Muscle Performance in Young Adults
• Interventions: Dietary Supplement: Creatine; Dietary Supplement: Placebo

• Registration Number: NCT06604793
• Lead Sponsor: University of Regina

Brief Summary

The purpose is to compare the effects of bolus ingestion (5 grams) vs. intermittent ingestion (2 x 2.5 grams) of creatine supplementation vs. placebo for 21 days on measures of body composition (lean tissue mass-indicator of muscle mass, total body water) and muscle performance (i.e., power, strength, endurance).

Detailed Description

Creatine is a naturally occurring compound produced in the liver and brain. Creatine can also be found in food products such as red meat and seafood or through commercially available manufactured creatine products (i.e. creatine supplementation).

Evidence-based research shows that creatine supplementation improves measures of body composition and muscle performance. However, the optimal creatine supplementation protocol to achieve these benefits is unknown.

Study Timeline

• Study Start: 2024-08-20
• Status Verified: 2024-09
• Study First Submitted: 2024-09-17
• Study First Submitted QC: 2024-09-17
• Last Update Submitted: 2024-09-17
• Study First Posted: 2024-09-20
• Last Update Posted: 2024-09-20
• Primary Completion: 2025-01-31
• Study Completion: 2025-01-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• if you are 18-39 years of age
• if you have not been performing resistance training for at least 4 weeks prior to the start of the study.

Exclusion Criteria

• if you are pregnant or nursing
• have taken creatine monohydrate within 30 days prior to the start of the study
• if you have pre-existing allergies to the placebo (corn-starch maltodextrin)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Creatine Bolus	Creatine	(Serving 1: 5 grams of creatine monohydrate + 3 grams of placebo in the morning; Serving 2: 8 grams of placebo in the evening) for 21 days.
Creatine Intermittent	Creatine	(Serving 1: 2.5 grams of creatine monohydrate + 5.5 grams of placebo in the morning; Serving 2: 2.5 grams of creatine monohydrate + 5.5 grams of placebo in the evening) for 21 days.
Placebo	Placebo	(Servings 1: 8 grams of placebo in the morning; Serving 2: 8 grams of placebo in the evening) for 21 days.

Primary Outcome Measures

Name	Time	Method
Whole-body lean mass (kg)	baseline, day 21	Bioelectrical impedance analysis
Strength	baseline, day 21	1-repetition maximum leg press and chest press (kg)
Endurance	baseline, day 21	Repetitions to fatigue for leg press and chest press (total number)
Hydration	baseline, day 21	Total body water (kg) using bioelectrical impedance analysis
Power	baseline, day 21	Medicine Ball Throw (feet)

Trial Locations

Locations (1)

University of Regina; 🇨🇦 Regina, Saskatchewan, Canada