CCL19/MIP3beta and CCL20/MIP3alpha Levels in the Gingival Crevicular Fluid of the Patients With Stage III Grade B and C Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- CCL20/MIP3alpha(α) levels
研究概览
简要总结
This study aimed to determine CCL19/MIP3beta(β) and CCL20/MIP3alpha(α) in the gingival crevicular fluid (GCF) of the patients with different periodontitis phenotypes.
A total of 72 individuals, 24 with Stage III Grade B periodontitis (Group 1), 24 with Stage III Grade C periodontitis (Group 2), and 24 periodontally healthy (control group) (Group 3), were included in the study. GCF and clinical periodontal parameters were obtained at baseline. MIP3β and MIP3α levels in GCF were determined by ELISA.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 22 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Have at least 20 natural teeth, excluding third molars.
- •Periodontitis patients had at least two non-adjacent sites per quadrant with probing depth (PD) ≥ 5 mm and clinical attachment level (CAL) ≥ 5 mm with gingival inflammation, and alveolar bone loss affecting >30% of the teeth, as detected on clinical and radiographical examinations.
- •Periodontally healthy control group had no sign of gingival inflammation, no PD > 3mm and no evidence of attachment or bone loss
排除标准
- •History of systemic disease.
- •Regular use of any drugs which can effect the immune system or inflammatory response in the 6 months preceding the start of the study.
- •Periodontal treatment during last 6 months that could affect periodontal status.
- •History of radiotherapy or chemotherapy.
- •Current pregnancy, lactation or menopause.
结局指标
主要结局
CCL20/MIP3alpha(α) levels
时间窗: Baseline
CCL20/MIP3alpha(α) levels in the gingival crevicular fluid (GCF)
CCL19/MIP3beta(β) levels
时间窗: Baseline
CCL19/MIP3beta(β) levels in the gingival crevicular fluid (GCF) of the all groups
次要结局
- CCL19/MIP3beta(β) levels and clinical parameters(Baseline)
- CCL20/MIP3alpha(α) levels and clinical parameters(Baseline)
研究者
Prof.Dr. Figen ÖNGÖZ DEDE
Clinical Professor
T.C. ORDU ÜNİVERSİTESİ