Bacterial Reduction and Post Operative Endodontic-pain Using Different Kinematics

Not Applicable

Completed

• Conditions: Root Canal Infection
• Interventions: Other: root canal shaping

• Registration Number: NCT04990115
• Lead Sponsor: Ain Shams University

Brief Summary

This study was conducted to compare the antibacterial effect and degree of postoperative pain of single rotary and reciprocating file systems during endodontic therapy

Detailed Description

Introduction: Instrumentation kinematic is one of the many aspects of shaping files that underwent heavy development through the last decade. The impact of the type of motion used to drive shaping instruments was heavily studied but mostly in-vitro. More randomized clinical trials are needed to achieve a reliable body of data concerning the issue.

Aim: This study aimed to evaluate the effect of varying shaping files' kinematics on bacterial reduction, post-operative pain and the incidence of flare-ups. Methods: Necrotic, asymptomatic, single-rooted mandibular premolars with single canals were used in the study, where 46 patients were randomly allocated to two groups. In the first group, WaveOne Gold was used for mechanical preparation while One Shape was used in the second group. Samples were taken preoperatively (S1) and after chemomechanical preparation (S2). Bacterial reduction was evaluated and compared between both groups via culturing technique and quantitative analysis by real-time polymerase chain reaction (qPCR). Post-operative pain and the incidence of flare-ups were also evaluated using the visual analog scale (VAS) method.

Study Timeline

• Study Start: 2020-08-01
• Primary Completion: 2020-12-01
• Study Completion: 2021-03-01
• Study First Submitted: 2021-06-26
• Study First Submitted QC: 2021-08-03
• Study First Posted: 2021-08-04
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-05
• Last Update Posted: 2021-09-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• mandibular premolars
• single rooted
• single canalled
• necrotic pulps
• asymptomatic apical periodontitis

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Exclusion Criteria

• gross caries
• root/crown fracture
• sinus tract
• swelling
• intake of antibiotics within previous 3 months
• pain with percussion

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
rotation	root canal shaping	root canal preparation performed using rotating instruments
reciprocation	root canal shaping	root canal preparation performed using reciprocating instruments

Primary Outcome Measures

Name	Time	Method
bacterial reduction	up to 1 hour	pre-instrumentation and post-instrumentation bacterial cultures to detect change in bacterial count after root canal instrumentation with the different kinematics
post operative pain	after the treatment visit by 72 hours	Visual analogue scale from 0-100 where 0 is the lowest and 100 is the highest

Trial Locations

Locations (1)

Faculty of Dentistry. Ain Shams University; 🇪🇬 Cairo, Egypt