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临床试验/NCT06660797
NCT06660797招募中不适用

Effect of Different Irrigation Activating Techniques on Irrigant Penetration Depth and Microbial Reduction in Root Canals (Clinical Study)

Tanta University1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2024年6月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
30
试验地点
1
主要终点
measurment of penetration depth of irrigant

研究概览

简要总结

This in-vivo study aim to evaluate effect of different irrigation activating techniques on Irrigant Penetration Depth and Microbial Reduction in root Canals

详细描述

Chemomechanical preparation with removal of infected tissues and microbial biofilms is the corner stone of root canal treatment. Since mechanical instrumentation alone cannot adequately disinfect root canals, complete cleaning and shaping involves irrigation with chemicals together with mechanical instrumentation.

In addition to shaping the root canal, the aim of chemical-mechanical preparation of root canals is to eliminate vital or necrotic tissue, microorganisms and their products, and dentin debris that result from instrumentation. However, the complexity of root canal anatomy together with microbial infection hinder this purpose.

Primary endodontic infection is characterized by the presence of a wide range of microbial diversity dominated by anaerobes. The polymicrobial profile of pulp infection involves both Gram-positive and Gram-negative bacterial species.

Besides, the apical third of the root canal system typically has a complex morphology and is difficult to clean. So, it is important to bring irrigants into contact with the entire canal surfaces along its total micro anatomic complexity for effective action especially in the apical portions .

Irrigating solutions used during endodontic handling act through direct contact with the targeted bacteria. However, irrigants have inadequate penetration depth. It is highly desirable that chemical substances selected as endodontic irrigants have antimicrobial and organic tissue dissolution properties besides serving in the debridement of the root canal system and not being toxic to the tissues .Sodium hypochlorite (NaOCl) has been the gold standard for irrigation because of its ability to dissolve organic matter and high antimicrobial potential.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Care Provider)

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • • Asymptomatic vital/non vital teeth requiring root canal treatment.
  • Teeth with sound periodontal apparatus.
  • Teeth without pus or inflammatory exudates draining through the canal.
  • Teeth without anatomic variations.
  • Teeth with sinus tract.

排除标准

  • • Patients with any systemic diseases.
  • Pregnant or lactating patients.
  • Immunocompromised patients.
  • Apparently thin roots in which apical preparation with #40 or #50 file would be overzealous.
  • Patient allergic to anything used in this procedure especially rubber dam material and Iohexol (radiographic contrast media).
  • Retreatment cases. Teeth with calcified canals.

研究组 & 干预措施

• Group 1: Manual dynamic agitation by matching gutta-percha master cones

Active Comparator

matching gutta-percha master cones will be used in up and down motion 2mm amplitude at a frequency of 100 strokes during approximately 1 min in each prepared canal.

干预措施: Group1: A matching gutta-percha master cones will be used in up and down motion 2mm amplitude at a frequency of 100 strokes during approximately 1 min in each prepared canal. (Other)

Group 3: Easy Clean system activation

Active Comparator

EC instrument coupled to the countrangle handpiece and operated with a micromotor at approximately 20,000 rotations per minute in continuous rotation.

干预措施: Group 3:EasyClean system activation : EC instrument coupled to the countrangle handpiece and operated with a micromotor at approximately 20,000 rotations per minute in continuous rotation. (Other)

Group 2: XP-endo Finisher activation

Active Comparator

XP-endo Finisher used in continuous rotation for 1 minute accompanied with in-and-out movements of approximately 7-mm amplitude will be applied to the instrument according to the manufacturer's recommendations⁸

干预措施: Group2: XP-endo Finisher activation: The XP-endo Finisher instrument will be used in continuous rotation for 1 mintute (Other)

结局指标

主要结局

measurment of penetration depth of irrigant

时间窗: at the same 1 day visit

measurment the difference between the working length and penetration depth of irrigant

measurment of bacterial reduction following different irrigation activating techniques

时间窗: 24-28 hours after culturing

collection of 3 samples followed by culturing on blood agar and counting to calculate percentage of bacterial reduction

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Alaa Samy Abd Elsabour Alfky

Doctor

Tanta University

研究点 (1)

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