NCT04099225已完成不适用
Multiple Breath Washout (MBW) Using Sulfur Hexafluoride Reference Values and Influence of Anthropometric Parameters
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104
- 主要终点
- Lung clearance index (LCI) derived from multiple breath washout testing (MBW)
研究概览
简要总结
Multiple breath washout (MBW) using Sulphur hexafluoride (SF6) has the potential to reveal ventilation heterogeneity in obstructive lung disease which is frequent in patients with small airway disease. However, it is missed by commonly used tests with reference data being scarce and mostly restricted to younger collectives. We aimed to evaluate the influence of anthropometric parameters on SF6-MBW reference values in pulmonary healthy adults.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •no history of pulmonary disease
- •absence of dyspnoea, cough, thoracic pain
- •no self-reported smoking history
- •normal lung function testing
- •normal shape of flow-volume curve
- •normal shape of flow-pressure curve
- •FEV1/FVC >70% (forced expiratory volume in 1 second / forced vital capacity)
- •TLC > 80% of predicted (total lung capacity)
- •TLCO/VA > 80% of predicted (transfer factor corrected for ventilated alveolar volume)
- •R5 < 150% of predicted (resistance at 5Hz, impulse oscillometry)
- •as above, but with self-reported smoking history >10 pack years
排除标准
- •unwilling or unable to give informed consent
- •history of any respiratory disease
结局指标
主要结局
Lung clearance index (LCI) derived from multiple breath washout testing (MBW)
时间窗: 30 minutes
global ventilation heterogeneity
次要结局
- Conductive phase-III-slope (Scond) derived from multiple breath washout testing (MBW)(30 minutes)
- Acinar phase-III-slope (Sacin) derived from multiple breath washout testing (MBW)(30 minutes)
研究者
Dr. Frederik Trinkmann
Principal Investigator
Universitätsmedizin Mannheim
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