The Effects of Lactobacillus Plantarum on Cortisol, IgA and Alpha-amylase Levels in Human Saliva During Stress
Not Applicable
Completed
- Conditions
- Stress Reaction
- Interventions
- Dietary Supplement: Probiotic (Lactobacillus Plantarum)Dietary Supplement: Placebo
- Registration Number
- NCT02974894
- Lead Sponsor
- Lund University
- Brief Summary
In the present study the main goal has been to clarify the effect of the probiotic bacteria Lactobacillus plantarum 299v on the salivary cortisol level in young adults under examination stress. Salivary IgA from minor glands and in whole human saliva was measured as alternative marker of stress. The hypothesis was that the levels of cortisol would be reduced or stabilized in the test group in comparison to the placebo group where the cortisol levels were expected to increase due to the examination-induced stress. By contrast, the salivary IgA levels were expected to increase in the test group in comparison to the placebo group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 42
Inclusion Criteria
- adults
- studying at the University in Lund
- participation in ongoing examination period
Exclusion Criteria
- pregnancy
- intake of antibiotics
- medication with cortisone during the study period
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Probiotic Probiotic (Lactobacillus Plantarum) Capsules containing potato starch as a filler and Lactobacillus plantarum Placebo Placebo Capsules containing potato starch
- Primary Outcome Measures
Name Time Method The impact of Lactobacillus plantarum on the levels of stress-induced cortisol in saliva. Change from baseline in cortisol levels at 14 days
- Secondary Outcome Measures
Name Time Method