The Effects of Lactobacillus Plantarum on Cortisol, IgA and Alpha-amylase Levels in Human Saliva During Stress
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 主要终点
- The impact of Lactobacillus plantarum on the levels of stress-induced cortisol in saliva.
研究概览
简要总结
In the present study the main goal has been to clarify the effect of the probiotic bacteria Lactobacillus plantarum 299v on the salivary cortisol level in young adults under examination stress. Salivary IgA from minor glands and in whole human saliva was measured as alternative marker of stress. The hypothesis was that the levels of cortisol would be reduced or stabilized in the test group in comparison to the placebo group where the cortisol levels were expected to increase due to the examination-induced stress. By contrast, the salivary IgA levels were expected to increase in the test group in comparison to the placebo group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •studying at the University in Lund
- •participation in ongoing examination period
排除标准
- •pregnancy
- •intake of antibiotics
- •medication with cortisone during the study period
研究组 & 干预措施
Probiotic
Capsules containing potato starch as a filler and Lactobacillus plantarum
干预措施: Probiotic (Lactobacillus Plantarum) (Dietary Supplement)
Placebo
Capsules containing potato starch
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
The impact of Lactobacillus plantarum on the levels of stress-induced cortisol in saliva.
时间窗: Change from baseline in cortisol levels at 14 days
次要结局
未报告次要终点