A Comprehensive Study to Isolate Tumor-initiating Cells From Human Epithelial Malignancies
- Conditions
- Skin CancersBladder (Urothelial, Transitional Cell) Cancer Resectable (Pre-Cystectomy)Bladder CancerBladder (Urothelial, Transitional Cell) Cancer
- Registration Number
- NCT01060319
- Lead Sponsor
- Stanford University
- Brief Summary
We hypothesize that all human malignancies harbour a subpopulation of tumor initiating cells/cancer stem cells (CSCs) that drives tumor development and potentially recurrence or metastasis of the disease. The primary aim of this study is to develop strategies for prospective isolation/enrichment of CSCs from human tumors of different tissue origins. In addition, we will characterize the signaling pathways and/or tumor specific antigens that are specific for CSCs, in order to specifically target these CSCs as the endpoint of this study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
N/A. We will recruit all non-melanoma skin and bladder cancer patients that are recommended for surgical removal of tumor tissues. This includes patients from all ages, gender and ethnicity background. Our sample collection criteria based on the tumor size of individual (e.g. tumor samples will only be collected if it will not affect the pathological diagnosis or treatment procedures of patients).
N/A
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of cancer stem cells (CSCs) The current study does not include the active involvement of patients. Our study involves the collection of tumor samples from patients after surgical procedures.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Stanford University School of Medicine
🇺🇸Stanford, California, United States