Personal Precise Treatment on Psoriasis and Psoriatic Arthritis
Not Applicable
Not yet recruiting
- Conditions
- Dermatologic Disease
- Interventions
- Diagnostic Test: Markers data from PBMCs
- Registration Number
- NCT04915105
- Lead Sponsor
- Taichung Veterans General Hospital
- Brief Summary
Part of psoriasis and psoriatic arthritis patients treated with biologics and met primary failure. Therefore, we are going to create a cell based platform to evaluate the treatment effects of different biologics on psoriasis and psoriatic arthritis patients before prescribed by physicians
- Detailed Description
PBMCs isolated from psoriasis and psoriatic arthritis and incubated with Group A streptococcus and different biologics for 24 hours. Cytokines expression in the culture supernatants will be measured and the data can be reference for physician's prescription.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
-
- Healthy control without underline disease such as psoriasis and psoriatic arthritis. 2. Psoriasis been diagnosed for over six months and PASI >10. 3.Psoriatic arthritis been diagnosed for over six months and >1 swallow and tender joints
Exclusion Criteria
- nil
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Prescreen on psoriasis and psoriatic arthritis treatment Markers data from PBMCs Prescreen markers from individual PBMCs and choose proper biologics before starting treatment on psoriasis and psoriatic arthritis patients.
- Primary Outcome Measures
Name Time Method swelling joint count and tenderness joint count 2 weeks to 3 months PSA severity
PASI score 2 weeks to 3 months Psoriasis skin condition and severity
- Secondary Outcome Measures
Name Time Method DLQI 6 months paper to investigate patient life quality
CRP 3-6 months blood test