NCT04915105尚未招募不适用
Personal Precise Treatment on Psoriasis and Psoriatic Arthritis and Investigate the Mechanisms of Biological Agents Induced Systemic Lupus Erythematosus
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 90
- 主要终点
- swelling joint count and tenderness joint count
研究概览
简要总结
Part of psoriasis and psoriatic arthritis patients treated with biologics and met primary failure. Therefore, we are going to create a cell based platform to evaluate the treatment effects of different biologics on psoriasis and psoriatic arthritis patients before prescribed by physicians
详细描述
PBMCs isolated from psoriasis and psoriatic arthritis and incubated with Group A streptococcus and different biologics for 24 hours. Cytokines expression in the culture supernatants will be measured and the data can be reference for physician's prescription.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy control without underline disease such as psoriasis and psoriatic arthritis.
- •Psoriasis been diagnosed for over six months and PASI >
- •3.Psoriatic arthritis been diagnosed for over six months and >1 swallow and tender joints
排除标准
- 未提供
结局指标
主要结局
swelling joint count and tenderness joint count
时间窗: 2 weeks to 3 months
PSA severity
PASI score
时间窗: 2 weeks to 3 months
Psoriasis skin condition and severity
次要结局
- DLQI(6 months)
- CRP(3-6 months)
研究者
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