Personal Precise Treatment on Psoriasis and Psoriatic Arthritis

Not Applicable

Not yet recruiting

• Conditions: Dermatologic Disease

• Registration Number: NCT04915105
• Lead Sponsor: Taichung Veterans General Hospital

Brief Summary

Part of psoriasis and psoriatic arthritis patients treated with biologics and met primary failure. Therefore, we are going to create a cell based platform to evaluate the treatment effects of different biologics on psoriasis and psoriatic arthritis patients before prescribed by physicians

Detailed Description

PBMCs isolated from psoriasis and psoriatic arthritis and incubated with Group A streptococcus and different biologics for 24 hours. Cytokines expression in the culture supernatants will be measured and the data can be reference for physician's prescription.

Study Timeline

• Status Verified: 2021-05
• Study Start: 2021-05-31
• Study First Submitted: 2021-05-31
• Study First Submitted QC: 2021-05-31
• Last Update Submitted: 2021-05-31
• Study First Posted: 2021-06-07
• Last Update Posted: 2021-06-07
• Primary Completion: 2025-05-31
• Study Completion: 2025-05-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• 1. Healthy control without underline disease such as psoriasis and psoriatic arthritis. 2. Psoriasis been diagnosed for over six months and PASI >10. 3.Psoriatic arthritis been diagnosed for over six months and >1 swallow and tender joints

Exclusion Criteria

• nil

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
swelling joint count and tenderness joint count	2 weeks to 3 months	PSA severity
PASI score	2 weeks to 3 months	Psoriasis skin condition and severity

Secondary Outcome Measures

Name	Time	Method
CRP	3-6 months	blood test
DLQI	6 months	paper to investigate patient life quality