CVP-guided Aquapheresis for the Treatment of Acute Congestion in Heart Failure - A Pilot Study to Optimize Individualized Volume Depletion
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Changes in central venous pressure
研究概览
简要总结
The number of patients with acute congestion on chronic heart failure is increasing. Ultrafiltration has recently been proposed as an alternative approach for the stabilization of volume balance, especially in patients with imminent diuretic resistance.
There is increasing evidence that ultrafiltration may relief cardiac congestion with lesser effects on blood pressure and activation of renin angiotensin system, respectively . However, recent studies revealed conflicting results: demonstration the superiority of ultrafiltration in comparison to diuretic treatment, and a lack of evidence of benefit, as well as an excess of adverse events with ultrafiltration.
Aquapheresis with adapted ultrafiltration rate guided by central venous pressure is safer than aquaphesis with a constant ultrafiltration with comparable effectiveness
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with chronic heart failure scheduled for LVAD
- •Indication for CVVH/Aquapheresis
排除标准
- •Renal Disease (GFR <20 ml / min)
结局指标
主要结局
Changes in central venous pressure
时间窗: Changes from Baseline to 48 h after intervention
次要结局
- Serum Creatinine level(48 h)
- amount of net fluid loss(48 h)
- heart rate(Changes from Baseline to 48 h after intervention)
- heart function(7 days)
- Biomarker(Changes from Baseline to 48 h after intervention)
- Time until impaired plasma refill rate(48 h)
- Measure of dyspnea using a visual analog scale(Changes from Baseline to 48 h after intervention)
- blood pressure(Changes from Baseline to 48 h after intervention)
研究者
Klinik für Kardiologie, Pneumologie und Angiologie
Klinik für Kardiologie, Pneumologie und Angiologie
Heinrich-Heine University, Duesseldorf