Dietary Nitrate Supplements and Ischemic Stroke Recovery: A Pilot Study
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Adherence With Intervention
研究概览
简要总结
This is a double-blind, randomized, placebo-controlled, pilot study. Participants will be randomized to receive either beetroot juice or a beetroot juice placebo, as a dietary supplement, for 30 days. Beetroot juice is high in nitrates, a chemical when ingested is found to increase blood flow to the brain. The purpose of this research study is to determine the safety and feasibility of using this nutritional intervention in (ischemic)stroke survivors, and prove that plasma levels of nitrate and nitrite increase as expected. Secondary outcomes includes measuring a comprehensive set of outcomes related to functional status post-stroke, including mobility, upper extremity strength, cognition, depression, and disability. Patients will also be randomized to MRI perfusion scanning in the region of the stroke to measure cerebral blood flow.
详细描述
In this proof of concept study, the investigators will for the first time, determine whether dietary nitrate (commercially available beetroot juice) is safe and feasible to administer in ischemic stroke patients, and whether its use is associated with increased plasma nitrate and nitrite levels and trends toward improvement during the standard 30-day rehabilitation period after a stroke. The investigators will test the hypotheses using a double-blinded randomized placebo-controlled trial of Beet It® shots once daily for 30 days for patients enrolled within 5 days of stroke onset. This novel study will provide key safety and feasibility data on dietary nitrate supplementation and preliminary information on the magnitude of its effect on improving mobility and functional status, cognition and cerebral blood flow. These data are needed to accelerate the pace of development of this novel therapeutic strategy: using a non-pharmacological approach for improving stroke outcomes. The specific aims are to: Aim 1) Test the proof of concept that beetroot juice consumption is feasible and safe in ischemic stroke patients when given during the post-acute rehabilitation period. Primary outcomes are adherence to the intervention, measurement of outcomes and follow-up (feasibility), as well as adverse events (safety), reported as proportions in each group and across the entire study cohort. Hypothesis: Beetroot juice is safe and feasible in this population, and leads to increased plasma nitrate and nitrite levels at 30 days. Secondary outcomes of interest include change in gait speed (m/sec), Modified Rankin score (disability scale), NIHSS, EuroQOL-5D (quality of life),Patient Health Questionnaire-9 (depression), Stroke Impact Scale-16 (SIS-16), Barthel Index, Short Physical Performance Battery, grip strength and the Montreal Cognitive Assessment (MoCA). Aim 2) Determine whether beetroot juice consumption increases cerebral blood flow vs. placebo juice. Cerebral blood flow will be determined from MRI collected 2 hours following ingestion of the beetroot juice on day 30. Anatomic and perfusion imaging (PASL) will be performed. A region of interest will be used to measure blood flow in a 20mm sphere placed adjacent to the ischemic stroke and in the contralateral hemisphere. Hypothesis: Ischemic stroke patients randomized to the beetroot juice intervention will show increased cerebral blood flow as measured by MRI perfusion scanning in the region of the stroke compared with the placebo group at 30 days.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients 18 years old and over
- •Diagnosed with an ischemic stroke (acute focal neurological deficit resulting from an ischemic cause, verified by CT or MRI)
- •Symptom onset within 5 days of admission
- •National Institutes of Health Stroke Scale Score of 2 or more (but less than 20)
- •A rating of fair or good on static sitting balance scale on a global balance scale
- •A score of more that 0 on the hip flexion on the short Fugl-Myer
- •Passed dysphagia screening for unrestricted or thickened liquids
排除标准
- •Patients with severe stroke (National Institutes of Health Stroke Scale Score of 20 or more)
- •A score of 0 on hip flexion on the Short Fugl-Myer as a result of weakness from the stroke
- •A rating of poor on static sitting balance scale on a global balance scale
- •Patients who received intravenous or intra-arterial recombinant tissue plasminogen activator (rtPA)
- •Patients who are receiving citicoline
- •Patients who have had a hemorrhagic stroke (including intraparenchymal, subarachnoid or subdural hemorrhage)
- •A gait speed of more > 0.8 m/s
- •Patient with evidence of brain tumor or other psychiatric or neurological condition that would interfere with outcome measures
- •Patients who will undergo carotid endarterectomy or other surgery during the study period
- •Patients not living independently prior to stroke
- •Survival is expected to be less than 6 months
- •Any patient on organic nitrate-containing medications; some examples of the medications that are exclusions include nitroglycerin, isosorbide mononitrate, sildenafil (Viagra), and tadalafil (Cialis)
- •Patients with atrophic gastritis
- •Patients with hypotension (blood pressure less than 100/60 mmHg)
- •Patients who do not pass the dysphagia screening test
研究组 & 干预措施
Beet It Beetroot Juice
70 cc (3.8 millimoles nitrate) Beet It organic beetroot juice once a day for 30 days. Vitamin C 500 mg (tablets) will be given along with each dose of the juice.
干预措施: Beet it Beetroot juice (Drug)
Beet It Beetroot Juice Placebo
70 cc Beet It organic beetroot juice (placebo) once a day for 30 days. The placebo beet juice is identical in appearance and taste with nitrate removed. Vitamin C 500 mg (tablets) will be given along with each dose of the juice.Beet It Placebo Beetroot juice.
干预措施: Beet It Placebo Beetroot juice (Drug)
结局指标
主要结局
Adherence With Intervention
时间窗: 30 days
The primary outcome for this trial is feasibility, which will be measured by how well the participants followed instructions on taking Beet It organic beetroot juice or placebo once a day for 30 days.
Number of Participants With Adverse Treatment-altering Events
时间窗: 30 days
Adverse events that lead to treatment discontinuation
Change in Plasma Nitrate Levels, Micromoles/Liter
时间窗: after 30 days of treatment
This is the proof-of-concept to see if plasma levels change in those randomized to the active beet juice compared to placebo. Comparing baseline values against values at 30 days.
Change in Plasma Nitrite Levels, Micromoles/Liter
时间窗: after 30 days of treatment
This is the proof-of-concept to see if plasma levels change in those randomized to the active beet juice compared to placebo. Comparing baseline values against values at 30 days.
次要结局
- Gait Speed Change From Baseline(baseline, 30, and 90 days)
- Cerebral Perfusion Imaging(30 days)
- Upper Extremity Grip Strength(90 days)
- Modified Rankin Score(90 days)
- Montreal Cognitive Assessment (MoCA) Score(90 days)