Effect of Local Injection of Tranexamic Acid on Surgical Field during Functional Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis: A Prospective Randomized Controlled Trial
Phase 4
- Conditions
- To study the results of local injection of tranexamic acid on surgical field quality during endoscopic sinus surgery in chronic rhinosinusitis patientsEndoscopic sinus surgery, FESS, Tranexamic acid, surgical field quality
- Registration Number
- TCTR20210531005
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 47
Inclusion Criteria
1.Being candidate for FESS based on EPOS 2020 criteria
2.Age 18 to 60 years
3.Hemoglobin > 10 mg/dl
4.Normal INR, PT, PTT
Exclusion Criteria
1.Having diathesis hemorrhage such as hemophilia
2.Having history of thrombosis
3.Acute or chronic renal failure
4.Using heparin during 48 hours before surgery
5.Using aspirin during 7 days before surgery
6.Allergy to TXA
7.Cirrhosis
8.Pregnancy
9.Having a cardiac stent
10.Having a nasal tumor
11.Patients who are unable to undergo surgery due to the opinion of an internist
12.Refuse to participate in OR withdraw from the research
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The quality of surgical field at 15, 30 and 45 minutes after the start of surgery Boezaart surgical field grading sysyem, Wormald surgical field grading system
- Secondary Outcome Measures
Name Time Method Operative blood loss at 15, 30 and 45 minutes after the start of surgery ml,Duration of surgery at the end of the operation of each side of the nose minute,Side effects 24 hours after operation questionnaire