Family Research Study: Metabolism of Fats and Proteins in Specific Ethnic Groups

Completed

• Conditions: Healthy; Heart Disease
• Interventions: Other: No intervention, observational study

• Registration Number: NCT00853775
• Lead Sponsor: University of California, Davis

Brief Summary

The purpose of this study is to determine whether lipoprotein(a), also called Lp(a), is a risk factor for cardiovascular (heart) disease. Lipoproteins are tiny particles that circulate in the blood. They contain cholesterol, fat, and protein in varying amounts depending on the body's need. Higher levels of lipoproteins in the blood can cause an increased risk of heart disease.

The investigators believe that by studying the Lp(a) lipoprotein in Caucasians and African Americans, the investigators can assess for genetic variation factors related to cardiovascular (heart) disease. The investigators will be looking at 100 African-American families and 100 Caucasian families to confirm whether a higher Lp(a) level is an indicator of a higher risk for heart disease.

Detailed Description

During the study visit the research staff will ask about the medical history, perform a brief physical exam, and draw approximately 4 teaspoons of blood of each family member.

Study Timeline

• Study Start: 2009-02
• Study First Submitted: 2009-02-25
• Study First Submitted QC: 2009-02-27
• Study First Posted: 2009-03-02
• Primary Completion: 2012-05
• Study Completion: 2012-12
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-25
• Last Update Posted: 2017-05-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 325

Inclusion Criteria

• Of Caucasian or African descent
• Families must have 2 natural/biological parents and 2 natural/biological offspring
• 6 years old or older

Exclusion Criteria

• Races other than African American or Caucasian
• Families without 2 natural/biological parents and 2 natural/biological offspring
• younger that 6 years old

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
African American Families	No intervention, observational study	Families with 2 parents and 2 children - no intervention, observational study
Caucasian Families	No intervention, observational study	Families with 2 parents and 2 children - no intervention, observational study

Primary Outcome Measures

Name	Time	Method
Genetic variation of Lp(a) levels in each group	five years

Trial Locations

Locations (1)

UC Davis CTSC Clinical Research Center (CCRC) at Veterans Affair Medical Center; 🇺🇸 Mather, California, United States