Microbial Profiling of Dental Plaque Around Natural Teeth Compared to That of Dental Implants: A Cross-sectional Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 3
- Locations
- 1
- Primary Endpoint
- Microbial profiling of Plaque
Study Overview
Brief Summary
The oral microbiome that colonizes the oral cavity plays a significant role in periodontal health and disease. Periodontitis is a site-specific disease and is initiated by dysbiosis of the subgingival microbiome. Peri-implantitis shares many similarities in pathogenesis with periodontitis. The presence of periodontitis is considered a risk factor for periimplantitis even though the exact mechanism is not clearly understood.
The possibility of microbial transmission for sites with periodontitis to the peri-implant crevice can not be negated. Microbial profiling of early colonizers around implants is poorly understood especially using next-generation sequencing techniques.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 20.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Systemically healthy patients with healing abutment of more than 2 weeks duration in at least one implant. Patients belonging to both sexes aged between
- •60 years. At least one periodontal site with pocket depth less than 3mm and no bleeding on probing. At least one periodontal site with pocket depth more than or equal to 4 mm with bleeding on probing.
Exclusion Criteria
- •Pregnant and lactating females Immunocompromised patients Smokers Use of probiotics, antibiotics, corticosteroids within 3 months before sampling.
Outcomes
Primary Outcomes
Microbial profiling of Plaque
Time Frame: Baseline (0) | 6 months
Secondary Outcomes
- FMPS(FMBS)
Investigators
Irine Paul
PMS College of Dental Science and Research